Mycorrhizal associations are essential for a successful development of most plants in various ecosystems. Therefore, it is highly important to study the effects of different substances on mycorrhizal fungi, especially in terms of a bioremediation. In modern days, a number of antropogenically generated substances which have toxic effects on mycorrhizal fungi is increasing. Mycorrhizal fungi have various mechanisms of tolerance to stress caused by pollution. The release of heavy metals in soil depends on various environmental conditions which means that the negative impact on mycorhizospheres will be variable. Hence, better understanding of endurance levels of stress in mycorrhizal fungi is needed along the mechanisms by which they reduce the negative effects of pollutants. The effects of substances that are more common in environment such as heavy metals have been more studied, however, more research should be done to study the effects of other classes of pollutants. Finally, it is important to mention that even though a lot of research has been done on isolates of fungi in laboratories, even more studies in the natural environment have to be made on this topic.