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undergraduate thesis
Inducirani animalni modeli u fiziologiji i imunologiji
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:407215
Derežić, Ivana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Derežić, I. (2015). Inducirani animalni modeli u fiziologiji i imunologiji (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:407215

Derežić, Ivana. "Inducirani animalni modeli u fiziologiji i imunologiji." Undergraduate thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:407215

Derežić, Ivana. "Inducirani animalni modeli u fiziologiji i imunologiji." Undergraduate thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:407215

Derežić, I. (2015). 'Inducirani animalni modeli u fiziologiji i imunologiji', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:407215

Derežić I. Inducirani animalni modeli u fiziologiji i imunologiji [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:407215

I. Derežić, "Inducirani animalni modeli u fiziologiji i imunologiji", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:407215

Metadata
TitleInducirani animalni modeli u fiziologiji i imunologiji
Title (english)Induced animal models in physiology and immunology
AuthorIvana Derežić
MentorNada Oršolić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Kroz povijest se je broj laboratorijskih životinja u istraživanjima povećavao, a s njime se povećavao i broj korištenih vrsta. Danas se životinje koriste kako bi se razumjela njihova biologija te kao organizmi za testiranje lijekova i drugih pojava s ciljem poboljšanja ljudskog zdravlja. Za gotovo svaku poznatu bolest u ljudi istraživači nastoje inducirati bolest sličnih karakteristika u životinja. S ciljem stvaranja takvih modela životinje se podvrgavaju raznim zahvatima koji uključuju operacije, traumatske ozljede, onemogućavanje pristupa hrani i vodi, socijalnu izolaciju, bakterijske i virusne zaraze te izlaganje radijaciji, kemikalijama ili toksičnim lijekovima. Dijabetes tipa I se u zdravih životinja može inducirati primjenom analoga glukoze, streptozotocina i aloksana, a dijabetes tipa II prehranom s povećanim udjelom masti. Ovarijektomija u štakora se najčešće primjenjuje u istraživanjima postmenopauzalne osteoporoze. Upalne bolesti crijeva, ulcerozni kolitis i Crohnova bolest mogu se inducirati pomoću octene i trinitrobenzensulfonske kiseline, indometacina i brojnih drugih spojeva. Istraživanje psorijaze je otežano nedostatkom prirodno javljajućeg poremećaja u laboratorijskih životinja koji oponaša složeni fenotip i patogenezu bolesti u ljudi, ali postoje neke kemijske tvari kojima se mogu prouzročiti simptomi karakteristični za psorijazu. Modeli bolesti središnjeg živčanog sustava se također mogu stvoriti. Miševi su se pokazali kao dobri modeli shizofrenije, Alzheimerove bolesti te Parkinsonove bolesti. Postoji nekoliko načina indukcije tumora u laboratorijskih životinja koji uključuju izlaganje radijaciji i kemijskim tvarima, virusne infekcije te transplantacije.
Abstract (english)
Number of laboratory animals was increasing during the history as well as number of used species. Today, animals are used to understand basic biology and as test subjects for the development and testing of drugs and other phenomena to improve human health. For practically every known human disease researchers attempt to induce similar aspects of the disease in animals. In order to create these models, animals are subjected to different procedures which include surgeries, traumatic injuries, food, water and social deprivation, viral and bacterial infections, exposing to radiation, chemicals or toxic drugs. Diabetes type I in animals can be induced by glucose analogues, streptozoticin or aloxan, while diabetes type II can be induced by high fat feeding. The ovariectomized rat model is most commonly used in research on postmenopausal osteoporosis. Inflammatory bowel diseses, Crohn´s disease and ulcerous colitis, are induced by chemicals like acetic and trinitrobenzenesulfonic acid, indomethacin and many other. Research into the pathogenesis of psoriasis has been hampered by the lack of a naturally occuring disorder in laboratory animals that mimics the complex phenotype and pathogenesis of the human disease. However, there are some chemicals that can induce certain symptoms which are common in psoriasis. Some central nervous system disease models can be also created. Mice are shown to be good models of schizophrenia, Alzheimer's disease and Parkinson’s disease. There are several ways to induce tumors in laboratory animals which include radiation and chemicals exposures, virus infections and transplantations.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:407215
Study programmeTitle: Environmental Sciences
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu)
Type of resourceText
File originBorn digital
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Created on2017-12-14 13:17:34