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undergraduate thesis
Transkripcijski faktor c-MYC – ključni regulator tumorigeneze
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:804353
Mojzeš, Anamarija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Mojzeš, A. (2015). Transkripcijski faktor c-MYC – ključni regulator tumorigeneze (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:804353

Mojzeš, Anamarija. "Transkripcijski faktor c-MYC – ključni regulator tumorigeneze." Undergraduate thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:804353

Mojzeš, Anamarija. "Transkripcijski faktor c-MYC – ključni regulator tumorigeneze." Undergraduate thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:804353

Mojzeš, A. (2015). 'Transkripcijski faktor c-MYC – ključni regulator tumorigeneze', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:804353

Mojzeš A. Transkripcijski faktor c-MYC – ključni regulator tumorigeneze [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:804353

A. Mojzeš, "Transkripcijski faktor c-MYC – ključni regulator tumorigeneze", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:804353

Metadata
TitleTranskripcijski faktor c-MYC – ključni regulator tumorigeneze
Title (english)Transcription factor c-MYC – key regulator of tumorigenesis
AuthorAnamarija Mojzeš
MentorPetra Korać (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
c-MYC gen smješten je na kromosomu 8, sastoji se od 3 eksona i kodira za transkripcijski faktor koji regulira ekspresiju mnogih gena. c-MYC ima važnu funkciju u kontroli rasta, diferencijacije i apoptoze stanica. Uključen je i u kontrolu staničnog metabolizma tako što kontrolira gene uključene u metabolizam glukoze i glutamina. Ukoliko dođe do promijenjene ekspresije MYC-a on mijenja globalnu gensku ekspresiju kroz regulaciju transkripcije što u konačnici dovodi do nastanka tipičnih tumorskih obilježja (nekontrolirani rast, besmrtnost, gubitak kontaktne inhibicije...) tj. do tumorigeneze. U mnogim ljudskim tumorima, uključujući tumore krvotvornih stanica i stanica imunosnog sustava, vezivnog tkiva, te epitelnog tkiva otkriveno je da dolazi do prekomjerne ekspresije c- MYC-a.
Abstract (english)
The c-MYC gene, located on human chromosome 8, has three exons. It codes for transcription factor that regulates expression of many genes. c-MYC has a pivotal function in growth control, differentiation and apoptosis in cells. It is involved in regulation of cell metabolism through control of expression of genes involved in glucose and glutamine metabolism. Deregulated MYC oncogene produces transcription factor that alters global gene expression through transcriptional regulation, resulting in formation of typical tumor characteristics (uncontrolled growth, immortality, loss of contact inhibition...) and induction of tumorigenesis. MYC is overexpressed in a majority of human tumors, including malignant neoplasms of lymphoid, mesenchymal and epithelial origin.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:804353
Study programmeTitle: Ecology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-12-15 11:36:03