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undergraduate thesis
Humanizacija biljnih N- i O-glikoziliranih proteina
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:127049
Zubčić, Klara
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Zubčić, K. (2015). Humanizacija biljnih N- i O-glikoziliranih proteina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:127049

Zubčić, Klara. "Humanizacija biljnih N- i O-glikoziliranih proteina." Undergraduate thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:127049

Zubčić, Klara. "Humanizacija biljnih N- i O-glikoziliranih proteina." Undergraduate thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:127049

Zubčić, K. (2015). 'Humanizacija biljnih N- i O-glikoziliranih proteina', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:127049

Zubčić K. Humanizacija biljnih N- i O-glikoziliranih proteina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:127049

K. Zubčić, "Humanizacija biljnih N- i O-glikoziliranih proteina", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:127049

Metadata
TitleHumanizacija biljnih N- i O-glikoziliranih proteina
Title (english)Humanization of N- and O-glycosylated plant proteins
AuthorKlara Zubčić
MentorBiljana Balen (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Glikanske strukture terapeutskih proteina utječu na njihova farmakodinamička i farmakokinetička svojstva. Optimalna glikozilacija povećala bi učinkovitost i sigurnost rekombinantnih farmaceutskih proteina. S obzirom na jeftiniji uzgoj i procesiranje, jednostavan N-glikozilacijski put i odsutnost O-glikozilacijskog puta karakterističnog za sisavce, biljke su se posljednjih godina nametnule u modeliranju ekspresijskog sustava za proizvodnju potpuno humaniziranih rekombinantnih terapeutskih proteina. Ciljevi pri konstruiranju takvog optimalnog sustava su inaktivacija gena za enzime karakteristične za biljnu glikozilaciju te uvođenje gena za enzime koji su karakteristični za čovjeka.
Abstract (english)
Glycan structures of therapeutic proteins affect their pharmacodynamics and pharmacokinetic characteristics. Optimal glycosylation would enhance efficiency and safety of recombinant pharmaceutical proteins. Due to inexpensive and simple cultivation, simple Nglycosylation pathway and absence of typical mammalian O-glycosylation pathway, in recent years plants have emerged as interesting new hosts for the production of fully humanized recombinant pharmaceutical proteins. Aims in engineering optimal expression system are inactivation of genes for plant-specific enzymes and introduction of enzymes that are humanspecific.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:127049
Study programmeTitle: Ecology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-12-19 10:17:37