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undergraduate thesis
Uloga pogrešno smotanih proteina u razvoju neurodegenerativnih bolesti
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:976053
Belačić, Katarina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Belačić, K. (2016). Uloga pogrešno smotanih proteina u razvoju neurodegenerativnih bolesti (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:976053

Belačić, Katarina. "Uloga pogrešno smotanih proteina u razvoju neurodegenerativnih bolesti." Undergraduate thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:976053

Belačić, Katarina. "Uloga pogrešno smotanih proteina u razvoju neurodegenerativnih bolesti." Undergraduate thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:976053

Belačić, K. (2016). 'Uloga pogrešno smotanih proteina u razvoju neurodegenerativnih bolesti', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:976053

Belačić K. Uloga pogrešno smotanih proteina u razvoju neurodegenerativnih bolesti [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:976053

K. Belačić, "Uloga pogrešno smotanih proteina u razvoju neurodegenerativnih bolesti", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:976053

Metadata
TitleUloga pogrešno smotanih proteina u razvoju neurodegenerativnih bolesti
Title (english)The role of misfolded proteins in neurodegenerative diseases pathology
AuthorKatarina Belačić
MentorIta Gruić-Sovulj (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2016, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Kako bi protein mogao izvršavati svoju biološku funkciju, on se mora pravilno smotati, odnosno zadobiti pravilnu trodimenzionalnu strukturu. Ako dođe do pogrešnog smatanja proteina kao posljedica može biti gubitak funkcije tog proteina, kriva lokalizacija unutar stanice, nepravilna razgradnja pogrešno smotanog proteina, promjena strukture kojom protein dobiva nova toksična svojstva i/ili akumulacija proteinskih agregata unutar ili izvan stanice. Mnoga patološka stanja kao izvor imaju problem pri smatanju proteina. Rezultati nedavnih istraživanja ukazuju da je mogući zajednički uzrok i patološki mehanizam različitih neurodegenerativnih bolesti pogrešno smatanje, agregacija i akumulacija proteina u mozgu koja rezultira apoptozom neurona. Cilj ovog završnog rada bio je istražiti postojeća saznanja o molekularnim mehanizmima i uzrocima pogrešnog smatanja i agregacije proteina, stanični odgovor na pogrešno smatanje i agregaciju proteina, uloga pogrešnog smatanja i agregacije proteina u neurodegeneraciji i potencijalnih ciljnih meta za terapiju neurodegenerativnih bolesti. Neurodegenerativne bolesti su povezane s akumulacijom pogrešno smotanih proteina unutar i izvan neurona i glija stanica u centralnom živčanom sustavu. Postavljene su tri hipoteze koje nastoje objasniti povezanost pogrešnog smatanja i agregacije proteina s neurodegeneracijom: hipoteza gubitka funkcije, hipoteza toksičnosti i hipoteza upale mozga kao posljedice pogrešnog smatanja i agregacije proteina. Unatoč velikom napretku u razumijevanju patogeneze neurodegenerativnih bolesti, dosada niti jedna nije izlječiva.
Abstract (english)
In order to fulfill their various biological roles, proteins must fold into precise three-dimensional structure. Failure to fold properly can either cause a loss of normal function, mislocalization, improper degradation, structural alterations that establish novel toxic functions and/or acumulation of protein aggregates inside or outside the cell. Many pathological conditions are fundamentally rooted in the protein folding problem. Recent evidence indicates that diverse neurodegenerative diseases for a common cause and pathological mechanism have misfolding, aggregation and acumulation of proteins in the brain resulting in neuronal apoptosis. The aim of this report was to review the existing knowledge of the molecular mchanisms and causes of protein misfolding and aggregation, cell methods for combating this problem, its role in neurodegeneration and the potential targets for therapeutic intervention in neurodegenerative diseases. Neurodegenerative diseases are associated with the acumulation of misfolded proteins inside and outside of the neuronal and glial cells in the central nervous system. Three hypothesis have been proposed to explain how protein misfolding and aggregation might be associated with neurodegeneration: the loss-of function hypothesis, the gain-of toxic function hypothesis and the brain inflammation hypothesis. Despite impressive progress in understanding the pathogenesis of neurodegenerative diseases, none of this disorders can be successfully treated.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:976053
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-12-22 10:56:12