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undergraduate thesis
Rad “na crno” unutarstaničnih proteina na staničnoj površini
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:608548
Funtak, Kristina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Funtak, K. (2016). Rad “na crno” unutarstaničnih proteina na staničnoj površini (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:608548

Funtak, Kristina. "Rad “na crno” unutarstaničnih proteina na staničnoj površini." Undergraduate thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:608548

Funtak, Kristina. "Rad “na crno” unutarstaničnih proteina na staničnoj površini." Undergraduate thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:608548

Funtak, K. (2016). 'Rad “na crno” unutarstaničnih proteina na staničnoj površini', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:608548

Funtak K. Rad “na crno” unutarstaničnih proteina na staničnoj površini [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:608548

K. Funtak, "Rad “na crno” unutarstaničnih proteina na staničnoj površini", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:608548

Metadata
TitleRad “na crno” unutarstaničnih proteina na staničnoj površini
Title (english)Intracellular moonlighting proteins on the cell surface
AuthorKristina Funtak
MentorBiljana Balen (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2016, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Moonlighting proteini obuhvaćaju set multifunkcionalnih proteina koji izvršavaju dvije ili više biokemijskih funkcija, a nisu nastali genskim fuzijama, alternativnim prekrajanjima, proteolitičkim fragmentima ili su promiskuitetni enzimi. Moonlighting proteini sa sekundarnom funkcijom na staničnoj membrani su vrlo često nađeni slučajno tijekom proteomskih istraživanja. S obzirom da raste broj novootkrivenih MPCS-a istražene su, njihove primarne i sekundarne funkcije, razlike s obzirom na unutarstanične proteine i eventualne sličnosti s izvanstaničnim proteinima. Iako su neki mehanizmi funkcija razrađeniji kao u receptora za plazminogen, još puno MPCS-a ima nepoznate ili dovoljno nerazjašnjene funkcije. Uz napredak bioinformatike, omogućena je brža i preciznija identifikacija MPCS-a, što bi moglo dovesti do nalaženja većeg broja MPCS-a, i do razumijevanja njihove evolucije. Jedna od pretpostavka je da su nastali duplikacijom gena, ali to ne mora biti jednoznačno rješenje. Daljnja opsežna i sustavna istraživanja omogućit će razumijevanje evolucije i svojstava MPCS-a.
Abstract (english)
Moonlighting proteins comprise a subset of multifunctional proteins that perform two or more biochemical functions, that are not due to gene fusion, alternative splicing, proteolytic fragments or promiscuous enzymes activities. Intracellular proteins that moonlight on the cell surface have been identified by chance in proteomic researches. The number of new MPCSs is growing, and therefore their primary and secondary functions, differences with intracellular proteins, and possible similarities with extracellular proteins were investigated. Although we know some mechanism more elaborate, as the receptor for plasminogen, many of MPCSs has unknown or unexplained functions. The bioinformatics progresses allow faster and precise identification of the MPCSs, which could lead to discovery of a larger number of MPCSs, and to understanding of their evolution. One hypothesis is that gene duplication may have a role in the origin of the MPCSs, but it does not have to be the only explanation. Extensive and systematic experiments will allow better understanding of the evolution and the features of MPCSs.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:608548
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-01-02 09:41:08