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doctoral thesis
Fizikalno-kemijska karakterizacija omeprazola i njegovih soli
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:643206
Vrbanec, Tomislav
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Vrbanec, T. (2017). Fizikalno-kemijska karakterizacija omeprazola i njegovih soli (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:643206

Vrbanec, Tomislav. "Fizikalno-kemijska karakterizacija omeprazola i njegovih soli." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:643206

Vrbanec, Tomislav. "Fizikalno-kemijska karakterizacija omeprazola i njegovih soli." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:643206

Vrbanec, T. (2017). 'Fizikalno-kemijska karakterizacija omeprazola i njegovih soli', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:643206

Vrbanec T. Fizikalno-kemijska karakterizacija omeprazola i njegovih soli [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:643206

T. Vrbanec, "Fizikalno-kemijska karakterizacija omeprazola i njegovih soli", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:643206

Metadata
TitleFizikalno-kemijska karakterizacija omeprazola i njegovih soli
Title (english)Physico-chemical characterization of omeprazole and its salts
AuthorTomislav Vrbanec
MentorJože Grdadolnik (mentor)
strani drzavljanin: Nije dostupno
Committee memberVladimir Stilinović (predsjednik povjerenstva)
Committee memberJože Grdadolnik (član povjerenstva)
strani drzavljanin: Nije dostupno
Committee memberVlasta Mohaček-Grošev (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2017-12-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
U razvoju lijekova važno je izabrati najprimjereniju kristalnu formu aktivne tvari. Tvari, koje su stabilne samo u određenom pH području, predstavljaju izazov za razvoj formulacije. Istraživana molekula omeprazol spada u skupinu prazola; lijekova koji su inhibitori protonske pumpe u ljudskom organizmu, a njihovo je glavno obilježje snažno i dugotrajno smanjenje stvaranja želučane kiseline. Za prazole je poznato, da su osjetljivi na degradaciju u kiselom okruženju. Zato se u formulaciji stabiliziraju alkalnim dodacima ili se daju u obliku bazičnih soli. Priprava i karakterizacija bazičnih soli je potrebna u slučaju izravne uporabe u formulaciji, odnosno i za praćenje mogućeg zasoljavanja slobodne molekule. Za potrebe istraživanja sintetizirane su soli omeprazola iz skupine alkalijskih (Li, Na, K) i zemnoalkalijskih metala (Mg, Ca). Istražena su i fizikalno-kemijska svojstva pet soli, koristeći neke analitičke metode (Ramanovu i Fourier-transformiranu infracrvenu mikroskopiju, analizu na termopostolju, dinamičku sorpciju vlage, nuklearnu magnetsku rezonanciju, difrakciju rentgenskih zraka na polikristalnom uzorku, termogravimetriju, diferencijalnu pretražnu kalorimetriju te teorijski izračun vibracijskih frekvencija). Zaključeno je, da je vibracijska spektroskopija prikladna spektroskopska metoda, koja na točan, brz i nedestruktivan način određuje fizikalno-kemijske karakteristike omeprazola i njegovih soli.
Abstract (english)
In drug development, it is important to have a suitable crystalline form of the active substance. Substances that are stable only within a certain pH range are a challenge for the formulation developement. Omeprazole molecule belongs to the group of prazoles; drugs which are proton pump inhibitors in the human body, but their main characteristic is a strong and long-lasting reduction of gastric acid formation. For the prazoles, it is known to be sensitive to degradation in an acid environment. The formulation is then stabilized with alkaline additives or is used in the form of basic salts. Preparation and characterization of basic salts is needed in the case of use in the formulation and to monitor any possible salinization of free molecule. For purposes of this study, the salts of omeprazole from the group of alkali metal (Li, Na, K) and alkaline earth metals (Mg, Ca) were synthesized. Also the physicochemical properties of five salts were probed, using Fourier-transform infrared and Raman microscopy, hot stage, dynamic vapour sorption, nuclear magnetic resonance, thermogravimetry, diffferenctial scanning calorimetry and theoretical calculation of vibrational frequencies. It was found, that vibrational spectroscopy serves as appropriate spectroscopic tool which in accurate, quick and non-destructive way determines the physicochemical characteristics of omeprazole and its salts.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:643206
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent132 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-01-12 09:55:41