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master's thesis
Visokotlačna supramolekulska sinteza kokristalâ lamotrigina
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:062988
Topić, Edi
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Topić, E. (2018). Visokotlačna supramolekulska sinteza kokristalâ lamotrigina (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:062988

Topić, Edi. "Visokotlačna supramolekulska sinteza kokristalâ lamotrigina." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:062988

Topić, Edi. "Visokotlačna supramolekulska sinteza kokristalâ lamotrigina." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:062988

Topić, E. (2018). 'Visokotlačna supramolekulska sinteza kokristalâ lamotrigina', Master's thesis, University of Zagreb, Faculty of Science, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:062988

Topić E. Visokotlačna supramolekulska sinteza kokristalâ lamotrigina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:062988

E. Topić, "Visokotlačna supramolekulska sinteza kokristalâ lamotrigina", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:062988

Metadata
TitleVisokotlačna supramolekulska sinteza kokristalâ lamotrigina
Title (english)High pressure supramolecular synthesis of lamotrigine co-crystals
AuthorEdi Topić
MentorVladimir Stilinović (mentor)
Committee memberVladimir Stilinović (predsjednik povjerenstva)
Committee memberHrvoj Vančik (član povjerenstva)
Committee memberJosip Požar (član povjerenstva)
Committee memberDominik Cinčić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2018-02-23, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Ispitane su mogućnosti visokotlačne statičke i udarne kompresije kao metode za pripravu kokristala lamotrigina, te uspoređene s mogućnostima uobičajenih metoda supramolekulske sinteze. Provedeno je pretraživanje kokristala lamotrigina kristalizacijom iz otopine, kristalizacijom iz taline te mehanokemijskom sintezom. Uzorci fizičke smjese lamotrigina i koformera obrađeni su statičkom kompresijom pri dva tlaka, te sporom i brzom udarnom kompresijom pri četiri različite brzine projektila. Dobiveni uzorci izučavani su metodom difrakcije rentgenskih zraka na praškastom uzorku, razlikovnom pretražnom kalorimetrijom te skenirajućom elektronskom mikroskopijom. Riješene su kristalne strukture za tri solvata i jedan kokristal lamotrigina metodom difrakcije rentgenskog zračenja na jediničnom kristalu. Visokotlačna sinteza i uobičajene metode sinteze uspoređene su prema broju uspješnih priprava, morfologiji i mehanizmu nastanka kokristala.
Abstract (english)
High-pressure static and shock compression was studied and compared with common methods used for supramolecular synthesis. Cocrystal screening of lamotrigine was done by crystallization from solution, crystallization from melt and mechanochemical synthesis. Physical mixture of lamotrigine and coformer was subjected to static compression at two pressures, as well as slow and fast shock compression at four different projectile speeds. Obtained samples were analysed with powder X-ray diffraction, differential scanning calorimetry and scanning electron microscopy. Crystal structure was solved for three solvates and one cocrystal of lamotrigine using single-crystal X-ray diffraction. High-pressure supramolecular synthesis and common methods of cocrystal preparation were compared by number of hits, morphology and formation mechanism of cocrystals.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:062988
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2020-02-23
Terms of useLicence In copyright icon
Created on2018-03-05 15:13:34