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undergraduate thesis
Nehomologni popravak DNA kod prokariota
Zagreb: University of Zagreb, Faculty of Science, 2009. urn:nbn:hr:217:388124
Bartulović, Ana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Bartulović, A. (2009). Nehomologni popravak DNA kod prokariota (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:388124

Bartulović, Ana. "Nehomologni popravak DNA kod prokariota." Undergraduate thesis, University of Zagreb, Faculty of Science, 2009. https://urn.nsk.hr/urn:nbn:hr:217:388124

Bartulović, Ana. "Nehomologni popravak DNA kod prokariota." Undergraduate thesis, University of Zagreb, Faculty of Science, 2009. https://urn.nsk.hr/urn:nbn:hr:217:388124

Bartulović, A. (2009). 'Nehomologni popravak DNA kod prokariota', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:388124

Bartulović A. Nehomologni popravak DNA kod prokariota [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2009 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:388124

A. Bartulović, "Nehomologni popravak DNA kod prokariota", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2009. Available at: https://urn.nsk.hr/urn:nbn:hr:217:388124

Metadata
TitleNehomologni popravak DNA kod prokariota
Title (english)DNA nonhomologous end-joining (NHEJ) system in prokaryotes
AuthorAna Bartulović
MentorIvana Ivančić Baće (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2009, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Mehanizmi popravka lomova DNA su detaljno proučavani zbog svoje važnosti na vijabilnost svih organizama u prirodi i njihovu genetičku stabilnost. Dva su najvažnija puta popravka lomova DNA; homologna rekombinacija (uz nisku stopu pogreške) te nehomologno spajanje krajeva (često popraćeno mutacijama). Opisan je sam model nehomolognog popravka koji uključuje dva najvažnija enzima, a to su protein Ku i ligaza LigD, koji stvaraju kompleks s dvolančanim lomovima DNA. Ligaza LigD ima tri katalitičke aktivnosti (polimeraznu, ligaznu i fosfoesteraznu) koje djeluju u popravljanju lomova. Međutim, nije sasvim sigurno jesu li ova dva proteina jedini uključeni u popravak.
Abstract (english)
DNA repair pathways of broken DNA have been intensely studied because of their importance for organism viability and genome integrity. The most important two pathways for repairing broken DNA are homologous recombination (error free) and nonhomologous end joining (error prone). Nonhomologous pathway includes two significant factors; Ku protein and LigD ligase that form a complex with DNA double strand breaks. LigD ligase has three catalytic activities (polimerase, ligase and phosphoesterase) that participate in the repair. However, it is not completely clear if these two proteins are the only participants in this repair mechanism.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:388124
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-03-06 09:33:21