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master's thesis
Karakterizacija raspršenih elemenata alfa-satelitne DNA u ljudskom genomu
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:577864
Zorić, Doris
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Zorić, D. (2018). Karakterizacija raspršenih elemenata alfa-satelitne DNA u ljudskom genomu (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:577864

Zorić, Doris. "Karakterizacija raspršenih elemenata alfa-satelitne DNA u ljudskom genomu." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:577864

Zorić, Doris. "Karakterizacija raspršenih elemenata alfa-satelitne DNA u ljudskom genomu." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:577864

Zorić, D. (2018). 'Karakterizacija raspršenih elemenata alfa-satelitne DNA u ljudskom genomu', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:577864

Zorić D. Karakterizacija raspršenih elemenata alfa-satelitne DNA u ljudskom genomu [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:577864

D. Zorić, "Karakterizacija raspršenih elemenata alfa-satelitne DNA u ljudskom genomu", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:577864

Metadata
TitleKarakterizacija raspršenih elemenata alfa-satelitne DNA u ljudskom genomu
Title (english)Characterization of dispersed alpha-satellite DNA in human genome elements
AuthorDoris Zorić
MentorĐurđica Ugarković (mentor)
Committee memberĐurđica Ugarković (predsjednik povjerenstva)
Committee memberZlatko Liber (član povjerenstva)
Committee memberGoran Kovačević (član povjerenstva)
Committee memberPetra Korać (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2018-02-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Satelitne DNA su uzastopno ponavljajuće sekvence koje su prisutne u dugačkim neprekinutim nizovima u genetički utišanim heterokromatinskim regijama. Projekti sekvenciranja genoma pokazali su prisutnost i distribuciju ponavljanja satelitne DNA u eukromatinskom dijelu genoma u blizini samih gena, odnosno raspršenost elemenata satelitne DNA u genomu. Prisutnost funkcionalnih elemenata poput promotora i mjesta vezanja transkripcijskih faktora unutar nekih satelita doveli su do pretpostavke da satelitne DNA mogu djelovati kao cis-regulatorni elementi ekspresije gena. Cilj istraživanja jest utvrditi zastupljenost i distribuciju raspršenih elemenata alfa-satelitne DNA u ljudskom genomu, uočiti moguće polimorfizme u populaciji te ispitati regulatornu ulogu tih elemenata analizom metilacije DNA prije i nakon temperaturnog stresa.
Abstract (english)
Satellite DNAs are tandemly repeated sequences present in long uninterupted arrays in genetically silenced heterochromatic regions. Genome sequencing projects revealed the presence and the distribution of repetitive satellite DNA in the vicinity of genes, or in other words, the dispersion of satellite DNA elements across the euchromatic portion of genome. The presence of functional elements such as promoters and transcription factors binding sites within a number of satelites led to assumption that satellite DNAs may act as gene expression cis-regulatory elements. The main goal of this research is to determine the abundance and the distribution of dispersed elements of alpha satellite DNA in human genome and to propose them as genetic polymorphisms in the population, as well as to investigate the potential regulatory role of those elements by DNA methylation analysis before and after the heat-shock treatment.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:577864
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-03-14 12:46:34