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undergraduate thesis
Paralozi aminoacil-tRNA-sintetaza
Zagreb: University of Zagreb, Faculty of Science, 2009. urn:nbn:hr:217:043221
Radman, Inja
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Radman, I. (2009). Paralozi aminoacil-tRNA-sintetaza (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:043221

Radman, Inja. "Paralozi aminoacil-tRNA-sintetaza." Undergraduate thesis, University of Zagreb, Faculty of Science, 2009. https://urn.nsk.hr/urn:nbn:hr:217:043221

Radman, Inja. "Paralozi aminoacil-tRNA-sintetaza." Undergraduate thesis, University of Zagreb, Faculty of Science, 2009. https://urn.nsk.hr/urn:nbn:hr:217:043221

Radman, I. (2009). 'Paralozi aminoacil-tRNA-sintetaza', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:043221

Radman I. Paralozi aminoacil-tRNA-sintetaza [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2009 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:217:043221

I. Radman, "Paralozi aminoacil-tRNA-sintetaza", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2009. Available at: https://urn.nsk.hr/urn:nbn:hr:217:043221

Metadata
TitleParalozi aminoacil-tRNA-sintetaza
Title (english)Paralogs of aminoacyl-tRNA synthetases
AuthorInja Radman
MentorIvana Weygand-Đurašević (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2009, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Aminoacil-tRNA-sintetaze ključni su enzimi u biosintetskom putu proteina i jedni od evolucijski najstarijih enzima. Analizama njima homolognih genskih sekvenci i proteinskih struktura utvrđeno je postojanje cijelog spektra tzv. krnjih paraloga, koji su funkcionalno uglavnom divergirali od svojih originala u više različitih smjerova. Ovim radom napravljen je osvrt na gotovo sve skupine otkrivenih paraloga te je izložena i komentirana funkcija, struktura i evolucija najzanimljivijih od njih. Paralozi su svrstani prema svojstvu homologije koju nose u dvije veće skupine, ovisno o tome sadrže li sekvencu homolognu katalitičkoj domeni odgovarajuće aaRS ili ne. Poseban je naglasak stavljen na nedavno otkrivene paraloge specifičnog metanogenog tipa seril-tRNA-sintetaza, čije su detaljne biokemijske i strukturalne analize upravo u tijeku.
Abstract (english)
Aminoacyl-tRNA synthetases are one of the key enzymes in protein biosynthesis and one of the evolutionary oldest enzymes as well. By analyses of their homologic sequences and protein structures, the existance of a wide spectrum of socalled truncated paralogs, which have mostly functionaly diverged from their originals into several different new pathways, has been shown. In this work a critical review of almost all groups of determined paralogs has been made. Also, function, structure and evolution of the most interesting ones has been established and commented. Paralogs have been divided into two larger subgroups based on their homology characteristics, depending on the homologous catalytic domain possesion. A special emphasis has been put on recently discovered methanogenic seryl-tRNA synthetases paralogs, whose detailed biochemical and structural analyses have just been in progress.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:043221
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-03-16 10:45:04