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undergraduate thesis
Indukcija pluripotentnih matičnih stanica
Zagreb: University of Zagreb, Faculty of Science, 2009. urn:nbn:hr:217:791407
Rešetar, Mirta
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Rešetar, M. (2009). Indukcija pluripotentnih matičnih stanica (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:791407

Rešetar, Mirta. "Indukcija pluripotentnih matičnih stanica." Undergraduate thesis, University of Zagreb, Faculty of Science, 2009. https://urn.nsk.hr/urn:nbn:hr:217:791407

Rešetar, Mirta. "Indukcija pluripotentnih matičnih stanica." Undergraduate thesis, University of Zagreb, Faculty of Science, 2009. https://urn.nsk.hr/urn:nbn:hr:217:791407

Rešetar, M. (2009). 'Indukcija pluripotentnih matičnih stanica', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:791407

Rešetar M. Indukcija pluripotentnih matičnih stanica [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2009 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:791407

M. Rešetar, "Indukcija pluripotentnih matičnih stanica", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2009. Available at: https://urn.nsk.hr/urn:nbn:hr:217:791407

Metadata
TitleIndukcija pluripotentnih matičnih stanica
Title (english)Induction of pluripotent stem cells
AuthorMirta Rešetar
MentorIvana Ivančić Baće (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2009, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Diferencirane somatske stanice mogu se reprogramirati u pluripotentne matične stanice uvođenjem reprogramirajućih faktora Oct3/4, Sox2, Klf4 i c-Myc ili Oct3/4, Sox2, Lin28 i Nanog direktno u somatske stanice. Znanstvenici su razvili nekoliko metoda reprogramiranja. Reprogramirajući faktori mogu se unijeti u stanicu kao transgeni pomoću virusnih ili plazmidnih vektora, uz posredstvo malih molekula koje poboljšavaju efikasnost reprogramiranja ili direkto kao rekombinantni proteini. Te metode omogućuju dobivanje pluripotentnih matičnih stanica različitih genetskih profila te bi se stoga mogle koristiti i u terapeutske svrhe. No prije toga potrebno je utvrditi molekularne i funkcionalne razlike između iPS i ES stanica, rasvijetliti mehanizme reprogramiranja i razviti sigurnije i efikasnije protokole indukcije.
Abstract (english)
Differentiated somatic cells can be reprogrammed into pluripotent stem cells by introduction of reprogramming factors Oct3/4, Sox2, Klf4 and c-Myc or Oct3/4, Sox2, Lin28 and Nanog directly into somatic cells. Scientists have developed several reprogramming methods. Reprogramming factors can be introduced into cells as transgenes with viral or plasmid vectors, in combination with small molecule compounds for enhanced efficiency of reprogramming, or directly as recombinant proteins. These methods enable establishment of pluripotent stem cells from different genetic background which would allow them to be used for therapeutic purposes. However, before that it would be necessary to determine molecular and functional differences between iPS and ES cells, understand mechanisms of reprogramming in detail and develope safer and more efficient protocols of induction.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:791407
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-03-16 11:14:33