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undergraduate thesis
Uloga centriola, centrosoma i trepetljika u nastanku nekih bolesti
Zagreb: University of Zagreb, Faculty of Science, 2010. urn:nbn:hr:217:993647
Vidan, Nikolina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Vidan, N. (2010). Uloga centriola, centrosoma i trepetljika u nastanku nekih bolesti (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:993647

Vidan, Nikolina. "Uloga centriola, centrosoma i trepetljika u nastanku nekih bolesti." Undergraduate thesis, University of Zagreb, Faculty of Science, 2010. https://urn.nsk.hr/urn:nbn:hr:217:993647

Vidan, Nikolina. "Uloga centriola, centrosoma i trepetljika u nastanku nekih bolesti." Undergraduate thesis, University of Zagreb, Faculty of Science, 2010. https://urn.nsk.hr/urn:nbn:hr:217:993647

Vidan, N. (2010). 'Uloga centriola, centrosoma i trepetljika u nastanku nekih bolesti', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:993647

Vidan N. Uloga centriola, centrosoma i trepetljika u nastanku nekih bolesti [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2010 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:217:993647

N. Vidan, "Uloga centriola, centrosoma i trepetljika u nastanku nekih bolesti", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2010. Available at: https://urn.nsk.hr/urn:nbn:hr:217:993647

Metadata
TitleUloga centriola, centrosoma i trepetljika u nastanku nekih bolesti
Title (english)Centrioles, centrosomes, and cilia in health and disease
AuthorNikolina Vidan
MentorVišnja Besendorfer (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2010, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Centrioli su valjkaste strukture okružene pericentriolarnom tvari koje izgrađuju centrosome, a centriol naslijeđen od majke ima ključnu ulogu u formiranju trepetljika. Potaknuti idejom Theodora Boveria o povezanosti centrosoma i raka, znanstvenici danas istražuju tu mogućnost pokušavajući otkriti što detaljnije osnovne mehanizme centrosoma, kao i povezanost s drugim bolestima. Bolesti koje se javljaju kao posljedica aberacija centriola često su rezultat nedostataka u samom nastanku centriola, u strukturi, funkciji i položaju centrosoma ili u formiranju i održavanju bičeva i trepetljika. Amplifikacija centrosoma je često svojstvo stanica raka jer potiče genetičku nestabilnost i nastanak tumora. Otkrivanje mutacija onkogena i tumorskih supresorskih gena može biti korisno u dijagnostici i praćenju liječenja. Svako otkriće na ovom području daje odgovore, nerijetko i otvara nova pitanja, ali nas u konačnici približava uspjehu u liječenju bolesti poput malignih tumora, kao i njihovom ranom otkrivanju.
Abstract (english)
Centrioles are barrel-shaped structures in matrix of protein (pericentriolar material), which form a core of centrosomes. They are important for forming cilia and flagella, as well. Following Theodor Boveri's idea of link between centrioles and human cancer, scientists are exploring that possibility and trying to find out details of basic mechanisms in centrosome and link with other diseases. Human diseases resulting from centriole aberrations reflect defects in centriole biogenesis, centrosome structure, function and positioning, or the formation and maintenance of cilia and flagella. Centrosome amplification is common feature of cancer cells driving genetic instability and tumorigenesis. Revealing oncogen mutations and tumor supressor genes can be useful in dignostic and treatment. Every finding in this area answers the questions, often asking new ones, but it is always a step forward to cure for tumors and their early discovery.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:993647
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-04 08:13:39