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master's thesis
Trombocitni serotonin i suicidalnost u ovisnika o alkoholu
Zagreb: University of Zagreb, Faculty of Science, 2010. urn:nbn:hr:217:746625
Šimčić, Oliver
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Šimčić, O. (2010). Trombocitni serotonin i suicidalnost u ovisnika o alkoholu (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:746625

Šimčić, Oliver. "Trombocitni serotonin i suicidalnost u ovisnika o alkoholu." Master's thesis, University of Zagreb, Faculty of Science, 2010. https://urn.nsk.hr/urn:nbn:hr:217:746625

Šimčić, Oliver. "Trombocitni serotonin i suicidalnost u ovisnika o alkoholu." Master's thesis, University of Zagreb, Faculty of Science, 2010. https://urn.nsk.hr/urn:nbn:hr:217:746625

Šimčić, O. (2010). 'Trombocitni serotonin i suicidalnost u ovisnika o alkoholu', Master's thesis, University of Zagreb, Faculty of Science, accessed 26 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:746625

Šimčić O. Trombocitni serotonin i suicidalnost u ovisnika o alkoholu [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2010 [cited 2024 April 26] Available at: https://urn.nsk.hr/urn:nbn:hr:217:746625

O. Šimčić, "Trombocitni serotonin i suicidalnost u ovisnika o alkoholu", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2010. Available at: https://urn.nsk.hr/urn:nbn:hr:217:746625

Metadata
TitleTrombocitni serotonin i suicidalnost u ovisnika o alkoholu
Title (english)Platelet serotonin and suicidality in alcoholic patients
AuthorOliver Šimčić
MentorNela Pivac (mentor)
MentorNada Oršolić (sumentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2010, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Abnormalna aktivnost središnjeg serotoninskog (5-HT) sustava povezuje se sa alkoholizmom, depresijom, impulsivnom agresivnošću i suicidalnim ponašanjem. Središnji serotonergički neuroni i trombociti dijele slične biokemijske procese, te se stoga u svrhu lakšeg proučavanja određenih psihopatoloških stanja vezanih za promjene središnjeg 5-HT ponekad koriste trombociti kao lako dostupan periferni model. Ovisnici o alkoholu su skloni razvitku suicidalnog ponašanja. Suicidalno je ponašanje u psihijatrijskih bolesnika povezano sa sniženom koncetracijom trombocitnog 5-HT. U studiji je sudjelovalo 359 muških i 90 ženskih ovisnika o alkoholu koji nisu uzimali nikakve lijekove, te 425 zdravih muških i 156 zdravih ženskih ispitanika. Ovisnici o alkoholu podijeljeni su prema spolu, komorbidnoj depresiji, suicidalnom ponašanju i suicidalnim pokušajima. Koncentracija trombocitnog 5-HT bila je značajno snižena u ovisnika o alkoholu prema kontrolnim ispitanicima, no nije se značajno razlikovala između ispitanika ovisnika o alkoholu sa ili bez suicidalnog ponašanja ili onih koji su pokušali ili nikad nisu pokušali počiniti suicid. Prema tome, rezultati su uputili na zaključak da se koncentracija trombocitnog 5-HT ne može koristiti kao periferni pokazatelj suicidalnog ponašanja u ovisnika o alkoholu.
Abstract (english)
Abnormal activity of the central serotonergic (5-HT) system is associated with alcoholism, depression, impulsivity, aggression and suicidal behavior. Central serotonergic synaptosomes and platelets share similar biochemical processes, and therefore platelets could be used as easy obtainable peripheral models for studies of particular psychopathologies related to alterations of the central 5-HT. Chronic alcoholic patients are prone to develop suicidal behavior. Suicidal behavior is associated with lower platelet 5-HT concentration in psychiatric patients. The study included 359 male and 90 female alcoholic, medication-free patients, and 425 healthy male and 156 healthy female control subjects. Chronic alcoholic subjects were subdivided according to the sex, comorbid depression, suicidal behavior and suicidal attempts. Platelet 5-HT concentration was significantly lower in chronic alcoholic patients than in healthy subjects, however it did not differ significantly between alcoholic patients with or without suicidal behavior, or between those who tried or did not try to attempt suicide. Therefore, these results suggested that platelet 5-HT concentration could not be used as a peripheral marker of suicidal behavior in alcoholic patients.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:746625
Study programmeTitle: Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra edukacije biologije (magistar/magistra edukacije biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-04 09:31:34