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undergraduate thesis
Uloga integrina u međustaničnoj komunikaciji i prijenosu signala
Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:334466
Božić, Tanja
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Božić, T. (2011). Uloga integrina u međustaničnoj komunikaciji i prijenosu signala (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:334466

Božić, Tanja. "Uloga integrina u međustaničnoj komunikaciji i prijenosu signala." Undergraduate thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:334466

Božić, Tanja. "Uloga integrina u međustaničnoj komunikaciji i prijenosu signala." Undergraduate thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:334466

Božić, T. (2011). 'Uloga integrina u međustaničnoj komunikaciji i prijenosu signala', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 12 March 2025, https://urn.nsk.hr/urn:nbn:hr:217:334466

Božić T. Uloga integrina u međustaničnoj komunikaciji i prijenosu signala [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2025 March 12] Available at: https://urn.nsk.hr/urn:nbn:hr:217:334466

T. Božić, "Uloga integrina u međustaničnoj komunikaciji i prijenosu signala", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:334466

Metadata
TitleUloga integrina u međustaničnoj komunikaciji i prijenosu signala
Title (english)Integrin function in cell communication and signalling
AuthorTanja Božić
MentorMaja Matulić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2011, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Primanje informacija iz neposredne okoline, kao i slanje informacija drugim stanicama, neizbježan je proces u živome svijetu. Mnogostanični organizmi imaju složenu zadaću, a to je uskladiti i regulirati prijenos signala između susjednih stanica, kako bi se održala homeostaza. Molekula koja ima važnu ulogu u obosmjernom prijenosu signala, iz okoline u stanicu i obratno, jesu integrini. To su heterodimerni, transmembranski receptori ograničeni na mnogostanične organizme. Građeni su od globularne,... More ekstracelularne glave, nožica i kratkog citoplazmatskog repa. Integrini se nalaze u tri alosteričke konformacije: inaktivna, savijena konformacija, intermedijarna i aktivna, ispružena konformacija. Vezanjem liganda za glavu integrina dolazi do konformacijske promjene, koja se prenosi duž molekule do citoplazmatske domene. Isto tako je moguće aktivirati vezno mjesto u glavi integrina, vezanjem efektorske molekule za citoplazmatski rep. Ovakav prijenos signala je dvosmjeran. Integrini su uglavnom adhezijski receptori, koji se vežu za proteine ekstracelularnog matriksa (ECM), pa je njihova osnovna funkcija stanična adhezija. Osim toga, oni sudjeluju u vezanju i remodeliranju citoskeleta, a time i pokretanju stanica. Kako je proces metastaze ovisan o staničnom usidrenju, očito je da integrini igraju važnu ulogu u invaziji stanica raka. Značajni su za indukciju apoptoze, ali isto tako pomažu u staničnom preživljenju. Nadalje, bitni su za staničnu proliferaciju, vezanje limfocita za endotel i prepoznavanju antigena. Očito je da su integrini važne molekule, koje sudjeluju u mnogim staničnim procesima. Oni su „senzori“ koji nadgledaju zbivanja u okolini i prenose signale u stanicu usmjeravajući njezino ponašanje. Less
Abstract (english)
Receiving information from the environment, as well as sending information to another cell is an inevitable process in the living world. Multicellular organisms have a complex task to coordinate and control signal transmission among neighbouring cells in order to maintain homeostasis. Integrins are important molecules which are involved in bidirectional signaling, from the environment to the cell and vice-versa. Integrins are heterodimer transmembrane receptors restricted to multicellular... More organisms. They are composed of a globular extracellular head domain, leg domain and short cytoplasmic domain. Integrins reside in three alosteric conformations: inactive bent conformation, intermediate and active extended conformation. Ligand binding to integrin head domain induces conformational change which is transmitted along the molecule to the cytoplasmic domain. It is also possible to activate the ligand binding site on the integrin head by efector binding to cytoplasmic tail. This kind of signal transfer is bidirectional. As they are generally adhesion receptors binding to proteins of extracelular matrix (ECM), main integrin function is cellular adhesion. Additionally, they participate in cytoskeleton binding and remodelling, thereby in cell migration. As metastasis is dependent on cellular anchorage it is evident that integrins play an important role in cancer cell invasion. Integrins are significant for apoptosis induction and help in cell survival. Furthermore, they are important for cell proliferation, lymphocyte binding to endotel cells and antigen recognition. Obviously, integrins are important molecules included in many cellular processes. They are „sensors“ which monitor events in the environment and transmit signals to direct cellular behavior. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:334466
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-05 09:18:19
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