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undergraduate thesis
Warburg efekt: metabolizam stanica raka
Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:134758
Križnik, Bojana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Križnik, B. (2011). Warburg efekt: metabolizam stanica raka (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:134758

Križnik, Bojana. "Warburg efekt: metabolizam stanica raka." Undergraduate thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:134758

Križnik, Bojana. "Warburg efekt: metabolizam stanica raka." Undergraduate thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:134758

Križnik, B. (2011). 'Warburg efekt: metabolizam stanica raka', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:134758

Križnik B. Warburg efekt: metabolizam stanica raka [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:134758

B. Križnik, "Warburg efekt: metabolizam stanica raka", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:134758

Metadata
TitleWarburg efekt: metabolizam stanica raka
Title (english)Warburg effect: cancer cells metabolism
AuthorBojana Križnik
MentorIta Gruić-Sovulj (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2011, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Prva istraživanja energetskog metabolizma tumora provodila su se 1922. godine u laboratoriju Otto Warburga. Warburg je ustanovio specifičan metabolizam stanica raka čija je karakteristika prijelaz s respiracije na fermentaciju - nazvan je Warburg-ov efekt. Wrburgov efekt predstavlja glavni razlog transformacije normalnih stanica u tumorske stanice. Tumorske stanice održavaju visoku razinu glikolize, čak i u uvjetima kada je doprema kisika stanicama dostatna, te akumuliraju velike količine laktata. Smatra se da je ovaj efekt važan za besmrtnost i transformaciju stanica, te omogućuje rezistentnost tumorskih stanica na oksidativni stres i adaptaciju stanica na uvjete hipoksije. Od vremena kada je otkriven ovaj fenomen, odvijala su se mnoga istraživanja koja su pomogla dubljem shvaćanju ovoga procesa. Bolje shvaćanje procesa iznjedrilo je mogućnosti dijagnoze i terapije, no još uvijek Warburgov efekt ne poznajemo dovoljno dobro. Ovaj rad predstavlja pregled činjenica i perspektive Warburg-ovog efekta u 21. stoljeću.
Abstract (english)
One of the first studies on the energy metabolism of tumors was carried out in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect, and that this is the main cause why normal cells become tumor cells. Here cells maintain a high glycolytic rate even in conditions of adequate oxygen supply, and accumulate large amounts of lactate. This seems to be important in immortalization and transformation of cell as it renders cells resistant to oxidative stress and adaptive to hypoxic condition. Considerable work has been done since Warburg first discovered this phenomenon, deepening our understanding of the process, with consequences for diagnosis and therapy, but still Warburg effect is not yet completely understood. This review presents facts and perspectives on the Warburg effect for the 21st century.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:134758
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-04-09 07:53:02