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master's thesis
Genotoksični učinci sevoflurana i izoflurana na stanice bubrega miša Swiss albino
Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:470148
Pavlić, Darko
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Pavlić, D. (2011). Genotoksični učinci sevoflurana i izoflurana na stanice bubrega miša Swiss albino (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:470148

Pavlić, Darko. "Genotoksični učinci sevoflurana i izoflurana na stanice bubrega miša Swiss albino." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:470148

Pavlić, Darko. "Genotoksični učinci sevoflurana i izoflurana na stanice bubrega miša Swiss albino." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:470148

Pavlić, D. (2011). 'Genotoksični učinci sevoflurana i izoflurana na stanice bubrega miša Swiss albino', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:470148

Pavlić D. Genotoksični učinci sevoflurana i izoflurana na stanice bubrega miša Swiss albino [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:470148

D. Pavlić, "Genotoksični učinci sevoflurana i izoflurana na stanice bubrega miša Swiss albino", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:470148

Metadata
TitleGenotoksični učinci sevoflurana i izoflurana na stanice bubrega miša Swiss albino
Title (english)Genotoxic effects of sevoflurane and isoflurane on kidney cells in Swiss albino mice
AuthorDarko Pavlić
MentorGordana Brozović (mentor)
MentorNada Oršolić (sumentor)
Committee memberNada Oršolić (član povjerenstva)
Committee memberVišnja Besendorfer (član povjerenstva)
Committee memberDamjan Franjević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2011, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U radu je istraživano oštećenje DNA stanica bubrega miša Swiss albino nakon višestrukog izlaganja inhalacijskim anesteticima sevofluranu i izofluranu. Za procjenu oštećenja DNA upotrijebljen je alkalni komet test, a praćena su 3 parametra: duljina repa (TL), repni moment (TM) i intenzitet repa (TI). Stupanj oštećenja DNA određivan je neposredno nakon izlaganja sevofluranu, odnosno izofluranu, te nakon 2 h, 6 h i 24 h. Srednje vrijednosti sva 3 parametra bile su statistički značajno više u eksperimentalnim skupinama u odnosu na kontrolne skupine, s tim da je kod miševa izloženih sevofluranu utvrđen kontinuiran porast oštećenja DNA unutar 24 h nakon izlaganja, dok je kod izoflurana najveće oštećenje opaženo 2 sata nakon izlaganja, nakon čega je došlo do popravka.
Abstract (english)
DNA damage of kidney cells in Swiss Albino mice after repeated exposure to inhalation anesthetics sevoflurane and isoflurane has been investigated. For evaluation of DNA damage alkaline comet assay has been used. Three parameters have been measured – tail length (TL), tail moment (TM) and tail intensity (TI), immediately after exposure to sevoflurane and isoflurane, as well as 2 h, 6 h and 24 h after exposure. Mean values of all three parameters have been significantly higher in experimental groups compared to the control groups. DNA damage in mice exposed to sevoflurane increased continuously within 24 h after exposure, while isoflurane induced highest DNA damage 2 h after exposure and afterwards DNA repair was observed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:470148
Study programmeTitle: Biology; specializations in: Molecular biology
Course: Molecular biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra biologije (magistar/magistra biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-09 11:48:31