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master's thesis
Polimorfizam gena za serotoninski prijenosnik u osoba oboljelih od epilepsije
Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:435639
Prodić, Jelena
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Prodić, J. (2011). Polimorfizam gena za serotoninski prijenosnik u osoba oboljelih od epilepsije (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:435639

Prodić, Jelena. "Polimorfizam gena za serotoninski prijenosnik u osoba oboljelih od epilepsije." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:435639

Prodić, Jelena. "Polimorfizam gena za serotoninski prijenosnik u osoba oboljelih od epilepsije." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:435639

Prodić, J. (2011). 'Polimorfizam gena za serotoninski prijenosnik u osoba oboljelih od epilepsije', Master's thesis, University of Zagreb, Faculty of Science, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:435639

Prodić J. Polimorfizam gena za serotoninski prijenosnik u osoba oboljelih od epilepsije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:217:435639

J. Prodić, "Polimorfizam gena za serotoninski prijenosnik u osoba oboljelih od epilepsije", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:435639

Metadata
TitlePolimorfizam gena za serotoninski prijenosnik u osoba oboljelih od epilepsije
Title (english)Serotonin Transporter Gene Polymorphism in Patients with Epilepsy
AuthorJelena Prodić
MentorJasminka Štefulj (mentor)
MentorDubravka Hranilović (sumentor)
Committee memberJasminka Štefulj (član povjerenstva)
Committee memberDubravka Hranilović (član povjerenstva)
Committee memberNataša Bauer (član povjerenstva)
Committee memberDamjan Franjević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2011, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Serotonin (5-HT) je neurotransmiter s ulogom u brojnim fiziološkim funkcijama, te u etiopatogenezi različitih neuropsihijatrijskih poremećaja. Razna istraživanja otkrila su sposobnost serotonina da utječe na nastanak i tijek epileptičkih napadaja. Serotoninski prijenosnik (5-HTT), transmembranski je protein odgovoran za uklanjanje serotonina iz sinaptičke pukotine, a smatra se glavnim regulatorom 5-HT neurotransmisije. Promotor i drugi intron gena za 5-HTT sadrže funkcionalne polimorfizme koji utječu na efikasnost genske ekspresije. Ovim radom ispitivana je njihova povezanost s epilepsijom temporalnog režnja (TLE). Istraživanjem je obuhvaćena 101 osoba oboljela od TLE-a i 155 zdravih osoba. Usporedbom frekvencija alela i genotipova promotorskog (5-HTTLPR) i intronskog (VNTR-2) polimorfizma gena za 5-HTT, nisu pronađene statistički značajne razlike između promatranih skupina. Dobiveni rezultati upućuju da istraživani polimorfizmi nemaju veliku ulogu u etiopatogenezi TLE-a u hrvatskoj populaciji, no zbog relativno malog broja ispitanika ne može se isključiti njihov mali utjecaj na etiopatogenezu ove kompleksne bolesti.
Abstract (english)
Serotonin is a neurotransmiter with a role in many physiological functions and in the etiopathogenesis of different neuropsychiatric disorders. Various studies have revealed the ability of serotonin to affect the generation and the course of epileptic seizures. Serotonin transporter (5-HTT), a transmembrane protein responsible for the removal of 5-HT from the synaptic cleft, is considered to be the main regulator of the 5-HT transmission. The promoter and the second intron of the 5-HTT gene contain functional polymorphisms that affect efficiency of the gene expression. The present work has investigated their association with the temporal lobe epilepsy (TLE). The study included 101 patients suffering from TLE and 155 healthy individuals. Comparison of allelic and genotypic frequencies of promoter (5-HTTLPR) and intron 2 (VNTR-2) polymorphisms, demonstrated no statistically significant difference between the investigated groups. These results indicate that investigated polymorphisms do not play a major role in the etiopathogenesis of TLE in Croatian population, however due to relatively small sample size, their minor effects on the etiopathogenesis of this complex disorder could not be excluded.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:435639
Study programmeTitle: Biology; specializations in: Molecular biology
Course: Molecular biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra biologije (magistar/magistra biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-10 09:51:26