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master's thesis
Socijalno i emotivno ponašanje štakora nakon perinatalne primjene tranilcipromina
Zagreb: University of Zagreb, Faculty of Science, 2011. urn:nbn:hr:217:382446
Čulig, Luka
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Čulig, L. (2011). Socijalno i emotivno ponašanje štakora nakon perinatalne primjene tranilcipromina (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:382446

Čulig, Luka. "Socijalno i emotivno ponašanje štakora nakon perinatalne primjene tranilcipromina." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:382446

Čulig, Luka. "Socijalno i emotivno ponašanje štakora nakon perinatalne primjene tranilcipromina." Master's thesis, University of Zagreb, Faculty of Science, 2011. https://urn.nsk.hr/urn:nbn:hr:217:382446

Čulig, L. (2011). 'Socijalno i emotivno ponašanje štakora nakon perinatalne primjene tranilcipromina', Master's thesis, University of Zagreb, Faculty of Science, accessed 03 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:382446

Čulig L. Socijalno i emotivno ponašanje štakora nakon perinatalne primjene tranilcipromina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2011 [cited 2025 January 03] Available at: https://urn.nsk.hr/urn:nbn:hr:217:382446

L. Čulig, "Socijalno i emotivno ponašanje štakora nakon perinatalne primjene tranilcipromina", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2011. Available at: https://urn.nsk.hr/urn:nbn:hr:217:382446

Metadata
TitleSocijalno i emotivno ponašanje štakora nakon perinatalne primjene tranilcipromina
Title (english)Social and emotional behaviour in rats after perinatal treatment with tranylcypromine
AuthorLuka Čulig
MentorDubravka Hranilović (mentor)
Committee memberPerica Mustafić (član povjerenstva)
Committee memberJasna Hrenović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2011, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Serotonin (5-hidroksitriptamin, 5-HT) je biološki aktivan amin. Nalazi se u mozgu i na periferiji gdje vrši različite fiziološke uloge, a također kontrolira razvoj mozga. Promjene u sustavu koji regulira metabolizam i funkciju 5-HT mogle bi predstavljati jednu od mogućih bioloških podloga poremećaja ponašanja u koje spada i autizam. Smatra se da visoka razina 5-HT u krvi, u doba fetalnog i ranog postanatalnog razvoja, može inhibirati rast i razvoj 5-HT neurona i tako dovesti do anatomskih i funkcionalnih promjena u mozgu. Kako bi se ispitale posljedice visoke razine 5-HT u krvi u doba perinatalnog razvoja na središnji odjeljak 5-HT, štakori su bili tretirani inhibitorom monoamin oksidaze (MAOI), tranilciprominom (TCP, 2mg/kg), od 13. embrionalnog do 21. postnatalnog dana života. U ovom radu smo istražili posljedice perinatalnog tretmana s MAOI na kognitivno, socijalno i emotivno ponašanje štakora. Eksperimentalne štakore tretirane TCP-om i kontrolne štakore tretirane fiziološkom otopinom podvrgnuli smo bateriji testova ponašanja kojima smo redom ispitali: učenje i kognitivnu rigidnost, lokomotorno ponašanje, anksioznost i eksploratorno ponašanje, socijabilnost te reakciju i habituaciju na opetovani zvučni podražaj. Skupina tretirana TCP-om pokazala je smanjenu razinu anksioznosti i kognitivne rigidnosti te povećanu razinu eksploratornog ponašanja i socijabilnosti u odnosu na kontrolnu skupinu. Razina lokomotornog gibanja nije se razlikovala između skupina. Rezultati pokazuju da je perinatalni tretman inhibitorom razgradnje serotonina utjecao na ponašanja regulirana serotoninom, što ukazuje na promjene u središnjem odjeljku 5-HT nastale tijekom razvoja mozga.
Abstract (english)
Serotonin (5-hydroxytryptamine, 5-HT) is a biologically active amine present in both brain and peripheral tissues where it serves different physiological functions and it also regulates brain development. Disruption of 5-HT metabolic pathway or impairments in its function could represent a base for different behavioral disorders including autism. During prenatal and early postnatal development, high concentrations of serotonin in blood could inhibit 5HT neuronal growth and differentiation and cause anatomical and functional changes in brain. To examine consequences of high blood 5-HT concentrations during perinatal development, rats were treated with monoamine oxidase inhibitor (MAOI), TCP (tranylcypromine, 2mg/kg) from 13th gestational day until 21st postnatal day. In this study we explored consequences of the mentioned perinatal treatment on cognitive, social and emotional behavior in rats. Experimental group (treated with TCP) and control group (treated with saline solution) of rats were submitted to the battery of tests. We examined learning and cognitive rigidity, locomotor activity, anxiety and exploratory behavior, sociability, and reaction and habituation to repeated high-frequency sound. Experimental group displayed significantly lower level of anxiety and cognitive rigidity, and showed higher sociability and exploratory behavior. Levels of locomotor activity did not differ between the groups. These results show that the treatment with TCP has influenced 5-HT-regulated behaviors, and indicate changes in the central 5-HT compartment that occurred during brain development.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:382446
Study programmeTitle: Biology; specializations in: Molecular biology
Course: Molecular biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra biologije (magistar/magistra biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-04-12 08:06:09