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undergraduate thesis
Metastaziranje tumorskih stanica
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:926222
Dodig, Helena
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Dodig, H. (2013). Metastaziranje tumorskih stanica (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:926222

Dodig, Helena. "Metastaziranje tumorskih stanica." Undergraduate thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:926222

Dodig, Helena. "Metastaziranje tumorskih stanica." Undergraduate thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:926222

Dodig, H. (2013). 'Metastaziranje tumorskih stanica', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 18 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:926222

Dodig H. Metastaziranje tumorskih stanica [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 December 18] Available at: https://urn.nsk.hr/urn:nbn:hr:217:926222

H. Dodig, "Metastaziranje tumorskih stanica", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:926222

Metadata
TitleMetastaziranje tumorskih stanica
Title (english)Metastatis of cancer cells
AuthorHelena Dodig
MentorInga Marijanović (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Rak je bolest kod koje se tjelesne stanice nekotrolirano razmnožavaju zbog poremećenih normalnih regulacijskih mehanizama. Maligni tumori infiltriraju se u okolna tkiva prodirući među zdrave stanice i mogu se kroz krv i limfne žile proširiti na udaljene dijelove tijela. Proces kojim maligne stanice migriraju s mjesta nastanka primarnog tumora u druge dijelove tijela naziva se metastaziranje. Metastaziranje obuhvaća invaziju, intravazaciju, transport, ekstravazaciju i metastatsku kolonizaciju. Ključni korak za preživljavanje tumora je angiogeneza, odnosno formiranje novih krvnih žila iz već postojećih. Svaki pojedini korak omogućen je brojnim genetskim i epigenetskim promjenama tumorskih stanica, kao i specifičnim interakcijama sa stromalnim stanicama pripadajućeg organa. Kako bi došlo do metastaziranja, potrebno je pronaći odgovarajuću mikrookolinu. Neki tumori kao svoje odredište za metastaziranje biraju prvi najbliži organ, budući da tumorske stanice na svom putu zbog veličine i raznih prepreka lako mogu zaglaviti unutar kapilara. Drugi pak metastaziraju na karakteristična, unaprijed određena mjesta, pri čemu se radi o genetski manipuliranim interakcijama između tumorskih stanica i receptora na stijenkama krvnih žila. Iako otprilike 1 od 3 osobe u nekom razdoblju svog života dobije rak, mnogi se mogu izliječiti zahvaljujući dostignućima u postavljanju dijagnoza i liječenju. Ovisno o vrsti i stadiju raka, terapija može biti namijenjena izliječenju, usporavanju rasta raka ili omogućavanju što ugodnijeg života. Dvije obećavajuće biološke terapije su genska terapija i angiogenska inhibicija. Razvijanje novih terapija koje će ciljno djelovati na produkte gena koji se eksprimiraju u određenim fazama rasta tumora omogućit će sprječavanje daljnjeg rasta i metastaziranje tumora.
Abstract (english)
Cancer is a disease in which somatic cells multiplicate uncontrollably due to disfunctional regulation mechanisms. A malignant tumor is capable of invading into adjacent tissues and may be capable of spreading to distant tissues through blood and lymph vessels. The process by which tumor cells from a primary site invade and migrate to other parts of the body is called metastasis. Tumor cells undergo several major steps during metastasis: invasion, intravasation, transport, extravasation, and metastatic colonization. Metastatic colonization cannot be successful without the formation of new blood vessels from pre-existing ones in a proces called angiogenesis. Each of these events is driven by the acquisition of genetic and epigenetic alterations within tumor cells and the co-option of nonneoplastic stromal cells. Metastases selectively colonize specific organs because of a ‘match’ between the migrating tumor cell and a suitable environment. As the bloodstream is the predominant means of long-distance transport and tumor cells can easily get stuck in the vasculature, organs in close proximity are likely to be main sites of metastasis for a particular primary tumor. On the contrary, the destination of metastasized cells can be genetically influenced by interactions between receptors lining the capillaries in certain a organ and tumor cells. Basic research findings have helped develop two new most promising therapies: gene and anti-angiogenic therapy. Developing new techniques which will target protein products of genes that are associated with primary tumor growth and risk of metastasis could give us hope of managing cancer.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:926222
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2018-04-23 09:31:23