This work presents a brief overview of historical review of the bacterial biofilm studies, their formation, transfer and presence in variety of environments and agents used for their control. Biofilms are important from a medical point of view, since our body surface, the teeth and our intestines are covered with bacteria that can potentially cause disease or contaminate medical equipment. Also, contamination of the surface is a major challenge in food production. There are different studying approaches of preventing their occurrence considering the problems they cause. Due to bacterial multiple resistance to antibiotics for years, the scientific aims are focused on finding chemical compounds which have bactericidal and bacteriostatic effect so as compounds that inhibit the bacterial binding to different surfaces and, therefore, the formation of biofilms. The most common researches that obtained the best results are those with chemical compounds such as silver (plasma deposition), D-Tyrosine (repellency activity), furanones (physical adsorption), a quaternary ammonium salt (covalent bonds), silica nanoparticles with quaternary ammonium salts (covalent bonds), trimethylsilane (plasma deposition with covalently), PLL-g-PEG (poly - L-lysine - graft - poly - ethylene glycol) and the silica colloids (superhydrophobic coating). It has been demonstrated that the biological - chemical approach is one of the most effective. Investigating the properties of anti-bacterial biomaterials and chemical compounds that have a major role in preventing the negative impact (illness, mortality) associated with infections caused by bacterial biofilms.