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master's thesis
Istraživanje supramolekulskih struktura tripeptida Phe-Phe-Ala infracrvenom spektroskopijom
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:280465
Paradžik, Ivana
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Paradžik, I. (2018). Istraživanje supramolekulskih struktura tripeptida Phe-Phe-Ala infracrvenom spektroskopijom (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:280465

Paradžik, Ivana. "Istraživanje supramolekulskih struktura tripeptida Phe-Phe-Ala infracrvenom spektroskopijom." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:280465

Paradžik, Ivana. "Istraživanje supramolekulskih struktura tripeptida Phe-Phe-Ala infracrvenom spektroskopijom." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:280465

Paradžik, I. (2018). 'Istraživanje supramolekulskih struktura tripeptida Phe-Phe-Ala infracrvenom spektroskopijom', Master's thesis, University of Zagreb, Faculty of Science, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:280465

Paradžik I. Istraživanje supramolekulskih struktura tripeptida Phe-Phe-Ala infracrvenom spektroskopijom [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:280465

I. Paradžik, "Istraživanje supramolekulskih struktura tripeptida Phe-Phe-Ala infracrvenom spektroskopijom", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:280465

Metadata
TitleIstraživanje supramolekulskih struktura tripeptida Phe-Phe-Ala infracrvenom spektroskopijom
Title (english)Study of supramolecular structures of Phe-Phe-Ala tripetides by infrared spectroscopy
AuthorIvana Paradžik
MentorLeo Frkanec (mentor)
MentorSnežana Miljanić (mentor)
Committee memberVesna Petrović Peroković (predsjednik povjerenstva)
Committee memberSnežana Miljanić (član povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberNives Galić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2018-07-02, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom diplomskom radu sintetizirani su metilni ester i amid, N-acetiltripeptidi aminokiselinskog slijeda L-fenilalanin-L-fenilalanin-L-alanin, koji se razlikuju prema funkcijskoj skupini na C kraju peptida. Aminokiselinski slijed FFA je dio amiloida β za koji je dokazano kako se nalazi u plakovima u mozgu pacijenata oboljelih od Alzheimerove bolesti. Kao model samoorganiziranja molekula amiloida, oba tripeptida su upotrijebljena za pripravu gelova u tri različita otapala, acetonitrilu, vodi i teškoj vodi. Infracrvenom spektroskopijom istražile su se sekundarne strukture tripeptida u pripremljenim gelovima, ponajprije analizom vrpce amid I u spektrima. Osim sekundarnih struktura, proučavana je i morfologija niti gelskih struktura pomoću transmisijskog elektronskog mikroskopa.
Abstract (english)
In this graduate thesis, methyl ester and amide were synthesised, N-acetyltripeptides with LPhenylalanine- L-Phenylalanine-L-Alanine sequence which differ depending on functional group at the C end of the peptide. The amino acid sequence FFA is part of the amyloid β in the brain plaques of patients with Alzheimer's disease. As a model of self-organization of the amyloid molecule, both tripeptides were used for the gels preparation in three solvents, acetonitrile, water and heavy water. Infrared spectroscopy was used to investigate the secondary structures of the tripeptide in prepared gels, mainly by analysis of amide I band. Also, gel morphology was studied usingtransmission electron microscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:280465
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2020-07-02
Terms of useLicence In copyright icon
Created on2018-07-11 12:22:53