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master's thesis
Dinamika nastanka diobenog vretena
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:249389
Kuzmić, Barbara
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Kuzmić, B. (2016). Dinamika nastanka diobenog vretena (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:249389

Kuzmić, Barbara. "Dinamika nastanka diobenog vretena." Master's thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:249389

Kuzmić, Barbara. "Dinamika nastanka diobenog vretena." Master's thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:249389

Kuzmić, B. (2016). 'Dinamika nastanka diobenog vretena', Master's thesis, University of Zagreb, Faculty of Science, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:249389

Kuzmić B. Dinamika nastanka diobenog vretena [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:217:249389

B. Kuzmić, "Dinamika nastanka diobenog vretena", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:249389

Metadata
TitleDinamika nastanka diobenog vretena
Title (english)Dynamics of mitotic spindle assembly
AuthorBarbara Kuzmić
MentorJasmina Rokov Plavec (mentor)
MentorIva Tolić (mentor)
Committee memberJasmina Rokov Plavec (predsjednik povjerenstva)
Committee memberIva Juranović Cindrić (član povjerenstva)
Committee memberJosip Požar (član povjerenstva)
Committee memberMarko Močibob (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2016-10-07, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Na početku diobe, stanica formira diobeno vreteno, molekularnu strukturu odgovornu za jednaku raspodjelu kromosoma među stanicama kćerima. To je vrlo kompleksna struktura koju čine mikrotubuli i pripadajući proteini. Tijekom prometafaze, kinetohorni mikrotubuli rastu iz polova diobenog vretena prema drugom kraju stanice i povezuju se s kinetohorama, multi-proteinskim strukturama na centromerama kromosoma. U ovom radu, fluorescencijska mikroskopija je korištena za vizualizaciju ljudskih stanica. Vizualizirane su i analizirane U2OS (CENP-A-GFP, mCherry--alpha-tubulin) stanice. Pokazano je da se duljina diobenog vretena smanjuje, a širina povećava tijekom prometafaze. Unatoč promjenama duljine i širine diobenog vretena, kontura ove stanične strukture ostaje nepromijenjena.
Abstract (english)
At the onset of division, the cell forms a spindle, a molecular machine responsible for equal distribution of chromosomes between the daughter cells. It is a highly complex structure made of microtubules and associated proteins. During prometaphase, kinetochore microtubules extend from poles on either end of the cell and attach to the kinetochores, multiprotein structures on the centromeres of the chromosomes. In this thesis, fluorescence microscopy was used for live-cell imaging of human cells. U2OS (CENP-A-GFP, mCherry-- alpha tubulin) cells were visualized and analyzed. It was shown that the spindle length decreases and the width increases during the prometaphase. Despite the changes in spindle length and width, the contour of this cell structure remains unchanged.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:249389
Study programmeTitle: Graduate Studies in Chemistry; specializations in: Research (scientific-professional) programme
Course: Research (scientific-professional) programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-01-26 12:39:05