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doctoral thesis
Raznolikost gena DRB, DQA i DQB skupine II glavnoga sustava tkivne podudarnosti u čaglja (Canis aureus)
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:865715
Celinšćak, Željka
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Celinšćak, Ž. (2018). Raznolikost gena DRB, DQA i DQB skupine II glavnoga sustava tkivne podudarnosti u čaglja (Canis aureus) (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:865715

Celinšćak, Željka. "Raznolikost gena DRB, DQA i DQB skupine II glavnoga sustava tkivne podudarnosti u čaglja (Canis aureus)." Doctoral thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:865715

Celinšćak, Željka. "Raznolikost gena DRB, DQA i DQB skupine II glavnoga sustava tkivne podudarnosti u čaglja (Canis aureus)." Doctoral thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:865715

Celinšćak, Ž. (2018). 'Raznolikost gena DRB, DQA i DQB skupine II glavnoga sustava tkivne podudarnosti u čaglja (Canis aureus)', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:865715

Celinšćak Ž. Raznolikost gena DRB, DQA i DQB skupine II glavnoga sustava tkivne podudarnosti u čaglja (Canis aureus) [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:865715

Ž. Celinšćak, "Raznolikost gena DRB, DQA i DQB skupine II glavnoga sustava tkivne podudarnosti u čaglja (Canis aureus)", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:865715

Metadata
TitleRaznolikost gena DRB, DQA i DQB skupine II glavnoga sustava tkivne podudarnosti u čaglja (Canis aureus)
Title (english)Diversity of the major histocompatibility complex class II DRB, DQA and DQB genes in golden jackal (Canis aureus)
AuthorŽeljka Celinšćak
MentorHaidi Arbanasić (mentor)
MentorTihomir Florijančić (komentor)
Committee memberAna Galov (predsjednik povjerenstva)
Committee memberIvana Buj (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2018-07-05, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Čagalj (Canis aureus) jedna je od najrasprostranjenijih vrsta iz porodice pasa (Canidae) u sjevernoj Africi, dijelovima Azije i jugoistočnoj Europi. U posljednjih nekoliko desetljeća dogodile su se značajne populacijske promjene čaglja u Europi koje uključuju opadanje broja, oporavak i ekspanziju čaglja. Kako bi se utvrdila mogućnost adaptacije i sposobnost dugoročnog preživljavanja populacija analizira se raznolikost gena glavnoga sustava tkivne podudarnosti (MHC) koji kodiraju bjelančevine uključene u prepoznavanje patogena i pokretanje imunološkog odgovora. U ovom istraživanju istražen je ekson 2 DRB1, DQA1 i DQB1 lokusa MHC regije skupine II kod 61 jedinke čaglja iz Dalmacije, Slavonije i Srbije. Utvrđena su 4 DRB alela, 2 DQA alela i 3 DQB alela, te 8 različitih haplotipova. Rezultati ukazuju na različitu genetičku raznolikost populacija čaglja iz Dalmacije i Slavonije, pozitivnu selekciju na svim lokusima i djelovanje ravnotežne selekcije.
Abstract (english)
The golden jackal is one of the most widespread canid species with distribution in northern Africa, parts of Asia and Southeastern Europe. In the past few decades the European golden jackal has undergone population size contraction and expansion. Genetic variability is thought to be essential to the long-term persistence and adaptability of populations. The major histocompatibility complex (MHC) genes are crucial for eliciting immune response and are the best adaptive markers for investigating population fitness. In this thesis the genetic diversity of the second exon of the MHC II loci DRB1, DQA1 and DQB1 was analyzed in 61 individuals. Four DRB, two DQA, three DQB alleles and eight haplotypes were detected. Various levels of MHC diversity in Slavonian and Dalmatian populations were found. In addition, sequences showed evidence for action of balancing selection through occurrence of trans-species polymorphism and significant excess of nonsynonymous substitution.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:865715
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-09-04 11:05:14