prikaz prve stranice dokumenta Priprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata
  Download
PDF 1.01 MB
master's thesis
Priprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:955110
Fržić, Ivana
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Fržić, I. (2016). Priprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:955110

Fržić, Ivana. "Priprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata." Master's thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:955110

Fržić, Ivana. "Priprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata." Master's thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:955110

Fržić, I. (2016). 'Priprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata', Master's thesis, University of Zagreb, Faculty of Science, accessed 09 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:955110

Fržić I. Priprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 November 09] Available at: https://urn.nsk.hr/urn:nbn:hr:217:955110

I. Fržić, "Priprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:955110

Metadata
TitlePriprava lipofilnih eterskih derivata 3-hidroksipiridin-4-ona i alkil-bromacetata
Title (english)Synthesis of lipophilic ether derivatives of pyridin-4-ones and alkyl bromoacetates
AuthorIvana Fržić
MentorVesna Petrović Peroković (mentor)
Committee memberVesna Petrović Peroković (predsjednik povjerenstva)
Committee memberSanda Rončević (član povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberSrđanka Tomić-Pisarović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2016-12-08, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovome diplomskom radu opisana je sinteza lipofilnih adamantilnih i cikloheksilnih derivata para-supstituiranih N-aril-3-hidroksi-2-metilpiridin-4-ona (1-4). Adamantilni i cikloheksilni lipofilni eteri pripravljeni su Williamsonovom sintezom iz polaznih piridinona 1-4 pri ĉemu je za uvoĊenje adamantilne jedinice korišten (adamantan-1-il)-bromacetat (5), a cikloheksilne cikloheksil-bromacetat (6). Iz spoja 1, 1-fenil-3-hidroksi-2-metilpiridin-4-ona, pripravljeni su adamantilni derivat 7 i cikloheksilni derivat 11. Spoj 2, 3-hidroksi-2-metil-1-(p-metilfenil)piridin-4-on, korišten je za pripravu adamantilnog derivata 8 i cikloheksilnog derivata 12. Adamantilni derivat 9 i cikloheksilni derivat 13 pripravljeni su iz polaznog piridinona 3, 3-hidroksi-2-metil-1-(p-metoksilfenil)piridin-4-ona. Spoj 4, 3-hidroksi-2-metil-1-(p-nitrofenil)piridin-4-on, korišten je kao polazni spoj za pripravu adamantilnog derivata 10 i cikloheksilnog derivata 14. Redukcijom nitro-derivata 10 i 14 pripravljeni su odgovarajući amino-eteri 15 i 16.
Abstract (english)
In this diploma thesis the synthesis of lipophilic adamantyl and cyclohexyl derivatives of para substituted N-aryl 3-hydroxy-2-methylpyridin-4-ones (1-4) is described. Adamantyl and cyclohexyl lipophilic ethers were prepared from starting pyridinones by Williamson synthesis. Adamantan-1-yl bromoacetate (5) and cyclohexyl bromoacetate (6) were used for introduction of adamantyl and cyclohexyl unit, respectively. Compound 1, 3-hydroxy-2-methyl-1-phenylpyridin-4-one was used as a starting compound in the preparation of adamantyl ether derivative 7 and cyclohexyl ether derivative 11. Compound 2, 3-hydroxy-2-methyl-1-(p-methylphenyl)pyridin-4-one, was used in the synthesis of adamantyl ether derivative 8 and cyclohexyl ether derivative 12. 3-Hydroxy-2-methyl-1-(p-methoxyphenyl)pyridin-4-one 3 served as a starting compound in the preparation of adamantyl ether derivative 9 and cyclohexyl ether derivative 13. Compound 4, 3-hydroxy-2-methyl-1-(p-nitrophenyl)pyridin-4-one, was used as a starting compound in the preparation of adamantyl ether derivative 10 and cyclohexyl ether derivative 14. Reduction of nitro groups of derivatives 10 and 14 resulted in formation of amino ethers 15 and 16, respectively.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:955110
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2018-12-08
Terms of useLicence In copyright icon
Created on2017-03-22 10:03:11