prikaz prve stranice dokumenta Ilegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe
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doctoral thesis
Ilegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:097592
Krizman, Ivona
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Krizman, I. (2015). Ilegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:097592

Krizman, Ivona. "Ilegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:097592

Krizman, Ivona. "Ilegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:097592

Krizman, I. (2015). 'Ilegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:097592

Krizman I. Ilegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:097592

I. Krizman, "Ilegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:097592

Metadata
TitleIlegalne droge i terapeutski opioidi u komunalnim otpadnim vodama – biogeokemijsko ponašanje i procjena zloporabe
Title (english)Illicit drugs and therapeutic opiates in municipal wastewaters - biogeochemical behaviour and estimation of drug abuse
AuthorIvona Krizman
MBZ: 330732
MentorSenka Terzić (mentor)
Committee memberVlasta Drevenkar (predsjednik povjerenstva)
Committee memberSenka Terzić (član povjerenstva)
Committee memberNives Galić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2015-06-12, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
Razvijena je analitička metoda za simultano odreĎivanje trinaest urinarnih biomarkera ilegalnih droga (heroin, kokain, kanabis, amfetamin, metamfetamin i 3,4-metilendioksimetamfetamin) i terapeutskih opioida (metadon i kodein) u komunalnoj otpadnoj vodi i mulju, kod niskih masenih koncentracija (ng L-1) primjenom vezanog sustava tekućinska kromatografija-tandemna spektrometrija masa (LC-MS/MS). Učinkovito obogaćenje analita iz uzoraka vode i suspendiranih čestica postignuto je ekstrakcijom na čvrstoj fazi, odnosno ubrzanom ekstrakcijom otapalom. Razvijena metoda primijenjena je za istraţivanje rasprostranjenosti i ponašanja istraţivanih spojeva u otpadnim vodama hrvatskih gradova te za praćenje obrazaca potrošnje i trendova zloporabe droga. Pokazano je da je većina analita stabilna u kanalizaciji, dok je njihovo uklanjanje na ureĎajima za pročišćavanje otpadnih voda variralo u rasponu od 4 % do 98 %. Analiza potrošnje droga pokazala je da je najraširenija zloporaba kanabisa, kokaina i heroina, a posljednjih je godina uočen i značajan porast potrošnje stimulirajućih droga amfetaminskog tipa.
Abstract (english)
A method, based on liquid chromatography-tandem mass spectrometry (LC-MS/MS), for the determination of low levels (ng L-1) of thirteen urinary biomarkers of illegal drugs (heroin, cocaine, cannabis, amphetamine, methamphetamine, 3,4- methylenedioxyamphetamine) and therapeutic opioids (methadone, codeine) in municipal wastewater and sludge was developed. Effective enrichment of analytes from wastewater and sludge samples was achieved using solid-phase extraction and accelerated solvent extraction, respectively. The method was applied to study occurence and biogeochemical behaviour of investigated compounds in the municipal wastewater of several Croatian cities as well as to investigate the drug consumption paterrns and trends. Model experiments indicated rather high stability of the investigated compounds in sewer systems, while their elimination in the wastewater treatment plants varied in a wide range (4 to 98 %). Drug consumption estimates indicated cannabis, cocaine and heroin as the most widely abused drugs, however recently a significant increase in amphetamine-type drugs was observed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:097592
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent191 str. ; 30 cm
File originBorn digital
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2018-09-05 16:19:30