prikaz prve stranice dokumenta Uloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica
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master's thesis
Uloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:630931
Gršković, Paula
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Gršković, P. (2018). Uloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:630931

Gršković, Paula. "Uloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:630931

Gršković, Paula. "Uloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:630931

Gršković, P. (2018). 'Uloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:630931

Gršković P. Uloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:630931

P. Gršković, "Uloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:630931

Metadata
TitleUloga gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica
Title (english)The influence of KIR genes on the outcome of haploidentical haematopoietic stem cell transplantation
AuthorPaula Gršković
MentorZorana Grubić (mentor)
Committee memberZorana Grubić (predsjednik povjerenstva)
Committee memberInga Marijanović (član povjerenstva)
Committee memberDijana Škorić (član povjerenstva)
Committee memberVesna Benković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2018-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Cilj ovog rada bio je istražiti polimorfizam i raspodjelu alela i haplotipova HLA-A, -B, -C, - DRB1 i -DQB1, gena i genotipova KIR i utjecaj gena KIR na ishod haploidentične transplantacije krvotvornih matičnih stanica (TKMS) među bolesnicima u programu liječenja haploidentičnom TKMS. Istraživanje je obuhvatilo 33 para (primatelj/davatelj). Učestalosti alela HLA među bolesnicima u skladu su s učestalostima u kontroli, uz neke iznimke. Većina bolesnika imala je barem jedan rijetki alel HLA (18; 54,5%) ili neuobičajeni haplotip HLAB~C (3; 9,1%) ili HLA-DRB1~DQB1 (4; 12,1%). Raspodjela gena KIR među bolesnicima odgovarala je raspodjeli među kontrolnim ispitanicima, pri čemu su geni KIR2DS5 i KIR3DS1 bili statistički značajno zastupljeniji u skupini bolesnika (P=0,0032, odnosno P=0,00229). Najčešće uočeni genotipovi KIR među bolesnicima bili su genotipovi AA1 i Bx2. Nije bila opažena statistički značajna razlika u preživljenju bolesnika ovisno o prisutnosti određenog aktivacijskog gena KIR u genotipu davatelja ni ovisno o genotipu KIR davatelja krvotvornih matičnih stanica.
Abstract (english)
The aim of this thesis was to investigate the polymorphism and frequency of HLA-A, -B, -C, - DRB1 and -DQB1 alleles and haplotypes, the polymorphism and frequency of KIR genes and genotypes and the influence of KIR genes on the outcome of haploidentical haematopoietic stem cell transplantation (HSCT) in patients included in the haploidentical HSCT program. There were 33 patient/donor pairs included in the study. The frequency of HLA alleles among patients matched the frequency in the control group, with some exceptions. Most patients had at least one rare HLA allele (18; 54,5%) or an unusual HLA-B~C haplotype (3; 9,1%) or HLA-DRB1~DQB1 haplotype (4; 12,1%). The frequency of KIR genes among patients matched the frequency in the control group, although KIR2DS5 and KIR3DS1 genes were significantly more frequent among patients (P=0,0032 and P=0,00229 respectively). The most frequent KIR genotypes observed among patients were AA1 and Bx2. There was no statistically significant difference in the survival of the patients depending on the presence of any particular activating KIR gene in the genotype of the donor or on the KIR genotype of the donor of haematopoietic stem cells.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:630931
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2020-09-13
Terms of useLicence In copyright icon
Created on2018-10-09 09:51:44