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doctoral thesis
Neuroimunomodularni učinak Toxoplasme gondii u shizofreniji
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:011792
Vlatković, Suzana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Vlatković, S. (2018). Neuroimunomodularni učinak Toxoplasme gondii u shizofreniji (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:011792

Vlatković, Suzana. "Neuroimunomodularni učinak Toxoplasme gondii u shizofreniji." Doctoral thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:011792

Vlatković, Suzana. "Neuroimunomodularni učinak Toxoplasme gondii u shizofreniji." Doctoral thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:011792

Vlatković, S. (2018). 'Neuroimunomodularni učinak Toxoplasme gondii u shizofreniji', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 07 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:011792

Vlatković S. Neuroimunomodularni učinak Toxoplasme gondii u shizofreniji [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 May 07] Available at: https://urn.nsk.hr/urn:nbn:hr:217:011792

S. Vlatković, "Neuroimunomodularni učinak Toxoplasme gondii u shizofreniji", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:011792

Metadata
TitleNeuroimunomodularni učinak Toxoplasme gondii u shizofreniji
Title (english)Neuroimmunomodulatory effect of Toxoplasma gondii in schizophrenia
AuthorSuzana Vlatković
MentorDubravka Švob Štrac (mentor)
Committee memberJulija Erhardt (predsjednik povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2018-09-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
Složena etiologija i biološka podloga shizofrenije te skromne spoznaje o utjecaju infekcija na razvoj ove bolesti, potaknule su ovo istraživanje neuroimunomodulatornog učinka parazita Toxoplasma gondii (TG) u shizofreniji. Rezultati upućuju da TG seropozitivni bolesnici imaju težu kliničku sliku bolesti, karakteriziranu većim brojem bolničkih liječenja, dužim psihijatrijskim tretmanom i češćom refrakternošću na terapiju. Međutim, TG seropozitivni bolesnici, usprkos starije dobi i češćeg uzimanja atipičnih antipsihotika, imaju nižu koncentraciju triglicerida, omjer triglicerida i lipoproteina visoke gustoće (HDL), opseg bokova i tjelesnu težinu, te posljedično i manji rizik razvoja kardiovaskularnih bolesti. U našem istraživanju nisu utvrđene statistički značajne razlike u koncentraciji trombocitnog serotonina i aktivnosti trombocitne monoaminooksidaze tipa B (MAO-B), kao niti u koncentraciji C reaktivnog proteina (CRP-a) i interleukina 6 (IL-6) između TG seropozitivnih i TG seronegativnih ispitanika sa shizofrenijom. Stoga su potrebna daljna istraživanja koja će dodatno razjasniti povezanost infekcije sa TG i razvoja shizofrenije.
Abstract (english)
Complex etiology and biological basis of schizophrenia, and modest knowledge regarding effects of infections on its development, stimulated this study of Toxoplasma gondii (TG) neuroimmunomodulatory effect in schizophrenia. Results suggest that TG seropositive patients have more severe clinical presentation, with higher number of hospitalisations, longer psychiatric treatment and more frequent treatment-resistance. However, TG seropositive patients, despite older age and more frequent usage of atypical antipsychotics, had lower triglyceride concentration, triglyceride/high-density lipoprotein cholesterol (HDL-C) ratio, hip circumference and body weight, suggesting lower risk for cardiovascular disease. No differences in concentrations of platelet serotonin levels and higher platelet monoamino oxidase type B (MAO-B) activity, as well as of C-reactive protein (CRP) and interleukin-6 (IL-6) levels between TG seropositive and TG seronegative subjects with schizophrenia were found. Further research is needed to further clarify the association between TG infection and development of schizophrenia.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:011792
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2020-09-26
Terms of useLicence In copyright icon
Created on2018-10-15 11:41:38