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master's thesis
Priprava etravirina, 3-fenilpiridina i 7-etiltriptofola protočnim sustavima
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:462176
Krajinović, Franjo
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Krajinović, F. (2018). Priprava etravirina, 3-fenilpiridina i 7-etiltriptofola protočnim sustavima (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:462176

Krajinović, Franjo. "Priprava etravirina, 3-fenilpiridina i 7-etiltriptofola protočnim sustavima." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:462176

Krajinović, Franjo. "Priprava etravirina, 3-fenilpiridina i 7-etiltriptofola protočnim sustavima." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:462176

Krajinović, F. (2018). 'Priprava etravirina, 3-fenilpiridina i 7-etiltriptofola protočnim sustavima', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:462176

Krajinović F. Priprava etravirina, 3-fenilpiridina i 7-etiltriptofola protočnim sustavima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:462176

F. Krajinović, "Priprava etravirina, 3-fenilpiridina i 7-etiltriptofola protočnim sustavima", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:462176

Metadata
TitlePriprava etravirina, 3-fenilpiridina i 7-etiltriptofola protočnim sustavima
Title (english)Preparation of etravirine, 3-phenilpyridine, and 7-etyltriptophol using flow reactors
AuthorFranjo Krajinović
MentorErnest Meštrović (mentor)
Committee memberVesna Petrović Peroković (predsjednik povjerenstva)
Committee memberErnest Meštrović (član povjerenstva)
Committee memberBranimir Bertoša (član povjerenstva)
Committee memberSanda Rončević (član povjerenstva)
Committee memberIvan Kodrin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2018-09-04, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Istražene su kemijske reakcije priprave poznatih spojeva: etravirina, 3-fenilpiridina i 7- etiltriptofola u protočnim reaktorima. Priprava etravirina najprije je uspješno provedena u šaržnom procesu uz kalijev karbonat kao bazu te je izrađen model praćenja reakcijske kinetike. Priprava etravirina u protočnom reaktoru nije bila uspješna ni nakon promjene baze (trietilamin i amonijak umjesto kalijeva karbonata). Priprava 3-fenilpiridina u protočnom reaktoru također je bila neuspješna zbog gubitka katalitičke moći korištenog katalizatora. Spoj 7-etiltriptofol uspješno je pripremljen u protočnom reaktoru te su optimirani reakcijski uvjeti. Konverzija reaktanta praćena je infracrvenom spektroskopijom i tekućinskom kromatografijom visoke učinkovitosti uz 7-etiltriptofol i etravirin kao standarde. Standardi su prethodno identificirani spektroskopijom protonske nuklearne magnetske rezonancije i tekućinskom kromatografijom spregnutom sa spektrometrijom masa.
Abstract (english)
Known chemical reactions were examined: etravirine, 3-phenylpyridine, and 7-ethyltryptofole in the flow reactors. Preparation of etravirine was first completed in a batch process with potassium carbonate as base and model for monitoring reaction kinetic was designed. Preparation of etravirine in flow reactor failed after the base change (triethylamine and ammonia). Preparation of 3-phenilpyridine failed due to depletion of the catalitic power of the catalyst. Compound 7-ethyltriptophol was successfully prepared and reaction conditions were optimized. The reactants conversion was monitored by means of the infrared spectroscopy and high-performance liquid chromatography. Compounds 7-ethyltryptofole and etravirine were used as reference standards. Standards were identified by means of proton nuclear magnetic resonance and liquid chromatography-tandem mass spectrometry.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:462176
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2020-09-25
Terms of useLicence In copyright icon
Created on2018-11-19 11:15:13