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doctoral thesis
Utjecaj hormona štitnjače na promjene karotidne krvožilne stijenke i metabolizam masti
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:300400
Seferović Šarić, Maida
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Seferović Šarić, M. (2018). Utjecaj hormona štitnjače na promjene karotidne krvožilne stijenke i metabolizam masti (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:300400

Seferović Šarić, Maida. "Utjecaj hormona štitnjače na promjene karotidne krvožilne stijenke i metabolizam masti." Doctoral thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:300400

Seferović Šarić, Maida. "Utjecaj hormona štitnjače na promjene karotidne krvožilne stijenke i metabolizam masti." Doctoral thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:300400

Seferović Šarić, M. (2018). 'Utjecaj hormona štitnjače na promjene karotidne krvožilne stijenke i metabolizam masti', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:300400

Seferović Šarić M. Utjecaj hormona štitnjače na promjene karotidne krvožilne stijenke i metabolizam masti [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:300400

M. Seferović Šarić, "Utjecaj hormona štitnjače na promjene karotidne krvožilne stijenke i metabolizam masti", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:300400

Metadata
TitleUtjecaj hormona štitnjače na promjene karotidne krvožilne stijenke i metabolizam masti
Title (english)The role of thyroid hormones in carotid wall remodeling and lipid metabolism
AuthorMaida Seferović Šarić
MentorVida Demarin (mentor)
Committee memberArijana Lovrenčić-Huzjan (predsjednik povjerenstva)
Committee memberDomagoj Đikić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2018, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Ateroskleroza je kronična bolest s progresivnim tijekom, razvoj koje počinje već u djetinjstvu, a obuhvaća čitav niz zbivanja koja rezultiraju zadebljanjem krvožilne stijenke, smanjenjem njezine elastičnosti i razvojem plaka. Kada taj proces zahvati karotidne arterije, dolazi do razvoja subkliničkih promjena na stijenkama arterije, koje se mogu kvantificirati mjerenjem debljine karotidnoga IMT-a uporabom ultrazvuka. Hormoni štitnjače utječu na kardiovaskularni sustav, no točni mehanizmi njihova utjecaja na razvoj ateroskleroze nisu u potpunosti jasni. U ovo je istraživanje bilo uključeno 100 žena, kojima su određene serumske koncentracije fT4, TSH, CRP-a, ukupnoga kolesterola, triglicerida, HDL-a, LDL-a i njegova podtipa sdLDL-a (za koji se smatra da ima izrazito proaterogeno djelovanje), te debljina karotidnoga IMT-a uporabom obojenoga doplera. Rezultati istraživanja potvrdili su hipotezu da ispitanice sa subkliničkom hipotireozom imaju poremećen metabolizam masti s povećanjem triglicerida, omjera kolesterol/HDL, sdLDL-a i karotidnog IMT-a u usporedbi s eutireoidnom skupinom ispitanica. Na temelju ovih rezultata može se zaključiti da je potreban probir, praćenja i eventualno liječenje osoba koje pokazuju rane, subkliničke znakove disfunkcije štitne žlijezde, te je potrebno, uz konvencionalne čimbenike rizika, provesti mjerenje i sdLDL-a.
Abstract (english)
Atherosclerosis is a chronic progressive disease, which develops in childhood, and which encompasses a whole range of processes that result in carotid wall thickening, reduction of its elasticity and development of plaque. When this process affects the carotid arteries, there is a development of subclinical changes on the arterial wall, which can be quantified by measuring the thickness of IMT with an ultrasound. Thyroid hormones affect the cardiovascular system, but the precise mechanisms of their effects on the development of atherosclerosis are not entirely clear. This research included 100 women whose serum concentrations of fT4, TSH, CRP, total cholesterol count, triglycerides, HDL, LDL and its subtype sdLDL (previously suggested to have highly atherogenic properties), as well as carotid IMT thickness using colour Doppler, have been determined. The results of this research confirmed the hypothesis that subjects with subclinical hypothyroidism have an imbalanced lipid metabolism with increased triglycerides, cholesterol/HDL ratio, sdLDL and carotid IMT, when compared with the euthyroid group. Based on these results we can conclude that there is a need to screen, track and eventually treat people showing early, subclinical signs of thyroid gland dysfunction, and that it is necessary, along with conventional risk factors, to measure sdLDL.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:300400
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2019-10-26
Terms of useLicence In copyright icon
Created on2018-12-13 12:14:57