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master's thesis
Sinteza novih heterocikličih beta-D-galaktokonjugata kao potencijalnih inhibitora butirilkolinesteraza. Homogena kataliza i nastava kemije.
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:939161
Kordić, Lorena
University of Zagreb
Faculty of Science
Department of Biology
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Kordić, L. (2017). Sinteza novih heterocikličih beta-D-galaktokonjugata kao potencijalnih inhibitora butirilkolinesteraza. Homogena kataliza i nastava kemije. (Master's thesis). Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:939161

Kordić, Lorena. "Sinteza novih heterocikličih beta-D-galaktokonjugata kao potencijalnih inhibitora butirilkolinesteraza. Homogena kataliza i nastava kemije.." Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:939161

Kordić, Lorena. "Sinteza novih heterocikličih beta-D-galaktokonjugata kao potencijalnih inhibitora butirilkolinesteraza. Homogena kataliza i nastava kemije.." Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:939161

Kordić, L. (2017). 'Sinteza novih heterocikličih beta-D-galaktokonjugata kao potencijalnih inhibitora butirilkolinesteraza. Homogena kataliza i nastava kemije.', Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:939161

Kordić L. Sinteza novih heterocikličih beta-D-galaktokonjugata kao potencijalnih inhibitora butirilkolinesteraza. Homogena kataliza i nastava kemije. [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:939161

L. Kordić, "Sinteza novih heterocikličih beta-D-galaktokonjugata kao potencijalnih inhibitora butirilkolinesteraza. Homogena kataliza i nastava kemije.", Master's thesis, University of Zagreb, Faculty of Science, Zagreb; University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:939161

Metadata
TitleSinteza novih heterocikličih beta-D-galaktokonjugata kao potencijalnih inhibitora butirilkolinesteraza. Homogena kataliza i nastava kemije.
Title (english)Synthesis of novel beta-D-galactoconjugates as potential butyrylcholinesterase inhibitors. Homogeneous catalysis and teaching chemistry.
AuthorLorena Kordić
MentorSrđanka Tomić-Pisarović (mentor)
MentorNenad Judaš (mentor)
Committee memberSrđanka Tomić-Pisarović (predsjednik povjerenstva)
Committee memberNenad Judaš (član povjerenstva)
Committee memberPerica Mustafić (član povjerenstva)
Committee memberBožena Mitić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2017-02-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U okviru istraživačkog dijela ovog diplomskog rada pripravljeni su novi heterociklički β-D-galaktokonjugati kao potencijalni inhibitori butirilkolinesteraza. U prvom koraku slobodne hidroksilne skupine D-galaktopiranoze zaštićene su acetiliranjem. Potom je na anomerni C-atom peracetilirane D-galaktopiranoze direktnom metodom O-glikozidacije uz BF3·Et2O kao aktivator vezan 2-brometanol do nastanka 1,2-trans galaktozida (β-anomer). Heterociklički spojevi (piridin, imidazol, benzimidazol te njihovi metilni i benzilni derivati) povezani su sa prethodno pripravljenim peracetiliranim β-D-galaktozidom i zatim su u posljednjem koraku uklonjene zaštitne skupine metodom po Zemplénu, natrijevim metoksidom u metanolu. Struktura i čistoća svih pripravljenih spojeva okarakterizirana je standardnim spektroskopskim analitičkim postupcima (IR, MS, NMR) te mjerenjem optičkog skretanja. U metodičkom dijelu rada osmišljen je prijedlog nastavnog sata na temu „Homogena kataliza“. Glavni i najčešći problem nastave na ovu temu je da se katalitička uloga tvari često pripisuje tvrdnjom, a ne prepoznaje se na temelju mjerenih podataka. Prijedlog nastavnog sata temelji se na strategiji učenja otkrivanjem i sadrži niz pokusa, kojima se omogućuje da učenici uz pomoć nastavnika, obave mjerenja, otkriju zakonitosti i prepoznaju katalitičku ulogu pojedinih tvari.
Abstract (english)
The scope of the thesis research part was the preparation of seven novel heterocyclic β-D-galactoconjugates as potential butyrylcholinesterase inhibitors. In the fisrt step, all hydroxyl groups of D-galactopyranose were protected by acetylation. Then 2-bromoethanole was attached to the anomeric C-atom of peracetylated D-galactopyranose, using the direct method of O-glycosylation, in the presence of BF3·Et2O as an activator, to form 1,2-trans galactoside (β-anomer). The heterocyclic compounds (pyridine, imidazole, benzimidazole and their 1-methyl and 1-benzyl derivatives) were attached to the previously synthesised acetylated β-D-galactoside and then, in the last step, the products were deacetylated following the Zemplén method, by adding sodium methoxide in methanol. The structures and purity of all obtained compounds were characterised by standard analytical procedures (IR, MS, NMR) and by optical rotation measurements. In the methodical part of the thesis, a proposition of a teaching lesson, on the subject matter of homogeneous catalysis, was designed. The main and the most common problem with teaching this subject matter is the practice of determing the catalytic properties of a compound by statements and not by the measurment data. The proposition of the teaching lesson is based on the strategy of inquiry learning with special emphasis on the use of experiments which allow students to collect the measurement data, discover the science laws and recognise the catalytic role of certain compounds.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:939161
Study programmeTitle: Integrated undergraduate and graduate university study of Biology and Chemistry Education; specializations in: Integrated undergraduate and graduate university study of Biology and Chemistry Education
Course: Integrated undergraduate and graduate university study of Biology and Chemistry Education
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-20 09:39:17