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master's thesis
Polimorfizimi gena TLR4 u tumorigenezi sporadičnog karcinoma debelog crijeva
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:036627
Salar, Anamarija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Salar, A. (2019). Polimorfizimi gena TLR4 u tumorigenezi sporadičnog karcinoma debelog crijeva (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:036627

Salar, Anamarija. "Polimorfizimi gena TLR4 u tumorigenezi sporadičnog karcinoma debelog crijeva." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:036627

Salar, Anamarija. "Polimorfizimi gena TLR4 u tumorigenezi sporadičnog karcinoma debelog crijeva." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:036627

Salar, A. (2019). 'Polimorfizimi gena TLR4 u tumorigenezi sporadičnog karcinoma debelog crijeva', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:036627

Salar A. Polimorfizimi gena TLR4 u tumorigenezi sporadičnog karcinoma debelog crijeva [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:036627

A. Salar, "Polimorfizimi gena TLR4 u tumorigenezi sporadičnog karcinoma debelog crijeva", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:036627

Metadata
TitlePolimorfizimi gena TLR4 u tumorigenezi sporadičnog karcinoma debelog crijeva
Title (english)TLR4 polymorphisms in sporadic colon cancer tumorigenesis
AuthorAnamarija Salar
MentorSanja Kapitanović (mentor)
MentorInga Marijanović (mentor)
Committee memberInga Marijanović (predsjednik povjerenstva)
Committee memberMartina Šeruga Musić (član povjerenstva)
Committee memberJasna Lajtner (član povjerenstva)
Committee memberBožena Mitić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2019-02-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Sporadični karcinom debelog crijeva je jedan od najčešćih zloćudnih tumora u svijetu. Receptor TLR4 je ključni regulator koji pomaže u održavanju ravnoteže između mikrobioma i imunološkog sustava crijeva. Poremećena homeostaza uslijed promijenjene ekspresije TLR4 bi mogla biti ključna značajka u patogenezi karcinoma debelog crijeva. Poznata su dva polimorfizma gena TLR4 +896A/G i +1196C/T za koje je pokazana povezanost s nastankom tumora. Cilj ovog diplomskog rada je ispitati postoji li povezanost polimorfizama +896A/G i +1196C/T sa sklonošću za obolijevanje od sporadičnog karcinoma debelog crijeva te postoji li povezanost s preživljenjem oboljelih. Rezultati nisu pokazali povezanost ispitivanih polimorfizama TLR4 s povećanim rizikom obolijevanja od sporadičnog karcinoma debelog crijeva niti s preživljenjem oboljelih. Učestalost varijantnih alela +896 G i +1196 T bila je statistički značajno veća kod zdravih ispitanika u odnosu na učestalost kod ispitanika oboljelih od sporadičnog karcinoma debelog crijeva. Homozigotni nosioci varijantnog alela +896 G i +1196 T bili su statistički značajno zastupljeniji u populaciji zdravih ispitanika. Genotipovi polimorfizama +896A/G i +1196C/T gena TLR4 su bili vezani na ispitivanoj populaciji te su se nasljeđivali u tri kombinacije genotipova (AA,CC; AG,CT i GG,TT).
Abstract (english)
Sporadic colon cancer is one of the most common malignant tumors in the world. TLR4 receptor is a key regulator that helps maintain balance between the microbial and immune system in the gut. Abnormal homeostasis in altered TLR4 expression could be a key feature in colon cancer pathogenesis. TLR4 polymorphisms +896A/G and +196C/T are known to be associated with tumorigenesis. The aim of this graduate thesis is to examine whether there is a correlation between polymorphisms +896A/G and +1196C/T and sporadic colon cancer susceptibility as well as with the patient's survival. Our results showed no correlation of TLR4 polymorphisms with sporadic colon cancer susceptibility or with survival. The incidence of variant alleles +896 G and +1196 T was significantly higher in healthy controls compared to patient's with sporadic colon cancer. Homozygous carriers of variant alleles +896 G and +1196 T were statistically significantly more present in the population of healthy controls. TLR4 polymorphisms +896A/G and +1196C/T cosegregate in our sample, and are inherited in three combinations of genotypes (AA,CC; AG,CT i GG,TT).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:036627
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-02-21
Terms of useLicence In copyright icon
Created on2019-03-26 10:03:24