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master's thesis
Učinak valproata na sustav antioksidacijske obrane u mozgu miša C57BI6
Zagreb: University of Zagreb, Faculty of Science, 2018. urn:nbn:hr:217:165236
Jurić, Dragan
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Jurić, D. (2018). Učinak valproata na sustav antioksidacijske obrane u mozgu miša C57BI6 (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:165236

Jurić, Dragan. "Učinak valproata na sustav antioksidacijske obrane u mozgu miša C57BI6." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:165236

Jurić, Dragan. "Učinak valproata na sustav antioksidacijske obrane u mozgu miša C57BI6." Master's thesis, University of Zagreb, Faculty of Science, 2018. https://urn.nsk.hr/urn:nbn:hr:217:165236

Jurić, D. (2018). 'Učinak valproata na sustav antioksidacijske obrane u mozgu miša C57BI6', Master's thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:165236

Jurić D. Učinak valproata na sustav antioksidacijske obrane u mozgu miša C57BI6 [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2018 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:165236

D. Jurić, "Učinak valproata na sustav antioksidacijske obrane u mozgu miša C57BI6", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:217:165236

Metadata
TitleUčinak valproata na sustav antioksidacijske obrane u mozgu miša C57BI6
Title (english)Effects of valproate on the antioxidative deffence system in the brain of C57Bl6 mouse
AuthorDragan Jurić
MentorDomagoj Đikić (mentor)
Committee memberDomagoj Đikić (predsjednik povjerenstva)
Committee memberTomislav Ivanković (član povjerenstva)
Committee memberDavor Zanella (član povjerenstva)
Committee memberŽeljka Vidaković-Cifrek (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2018-11-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Cilj rada bio je odrediti utjecaj valporata na antioksidacijsku obranu u mozgu miša. Dodatni cilj bio je istražiti da li primjena polifenola naringenina zajedno sa valproatom utječe na redoks ravnotežu te može li sinergistička aplikacija naringenina i valproata umanjiti potencijalne negativne učinke. Pokusima je izmjerena lipidna peroksidacija, koncentracija ukupnog glutationa te aktivnost antioksidativnog enzima superoksid dismutaze u prefrontalnom i centralnom korteksu i malom mozgu. Rezultati su pokazali da, tretman valproatom, naringeninom i njihovim kombinacijama uzrokuje povećanu lipidnu peroksidaciju i kod mužjaka i kod ženki u sve tri mjerene regije mozga. Protektivni učinak polifenolne molekule naringenina nije pokazan. Sukladno povećanoj lipidnoj peroksidaciji raste i aktivnost superokisd dismutaze u svim regijama mozga. Izrazito snižena koncentracija reduciranog glutationa u mozgu nastala je vjerojatno zbog povećanog superoksidnog radikala i oksidacijske ravnoteže u stanici te je glutation prešao iz reduciranog u oksidirani oblik.
Abstract (english)
Aim of this study was to determine effects of antioxidative defense in mouse brain (C57Bl6). An additional aim was to investigate whether the use of polyphenylene naringenine together with valproate affects the redox balance and whether the synergistic application of naringenine and valproate can reduce the potential negative effects. In this experiment lipid peroxidation, concentration of total glutathione and antioxidant activity of superoxide dismutase was measured in the prefrontal and central cortex and small brain. Results showed that the treatment with valproate and naringenine and their combinations caused increased lipid peroxidation in both males and females in all three measured brain regions. The protective effect of polyphenolic naringenine molecule has not been demonstrated. In accordance with increased lipid peroxidation, activity of superoxide dismutase in the brain has also increased. Reduced concentration of reduced glutathione in the brain was probably due to the increased superoxide radical and oxidation equilibrium in the cell and glutathione ranged from reduced to his oxidized form.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:165236
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2020-11-27
Terms of useLicence In copyright icon
Created on2019-03-28 11:33:01