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master's thesis
Evolucija ključnih peroksisomalnih proteina
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:704925
Mišetić, Hrvoje
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Mišetić, H. (2019). Evolucija ključnih peroksisomalnih proteina (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:704925

Mišetić, Hrvoje. "Evolucija ključnih peroksisomalnih proteina." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:704925

Mišetić, Hrvoje. "Evolucija ključnih peroksisomalnih proteina." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:704925

Mišetić, H. (2019). 'Evolucija ključnih peroksisomalnih proteina', Master's thesis, University of Zagreb, Faculty of Science, accessed 28 March 2025, https://urn.nsk.hr/urn:nbn:hr:217:704925

Mišetić H. Evolucija ključnih peroksisomalnih proteina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2025 March 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:704925

H. Mišetić, "Evolucija ključnih peroksisomalnih proteina", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:704925

Metadata
TitleEvolucija ključnih peroksisomalnih proteina
Title (english)Evolution of core peroxisomal proteins
AuthorHrvoje Mišetić
MentorToni Gabaldon (mentor)
MentorDamjan Franjević (mentor)
Committee memberDamjan Franjević (predsjednik povjerenstva)
Committee memberBiljana Balen (član povjerenstva)
Committee memberSilvija Černi (član povjerenstva)
Committee memberTomislav Ivanković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2019-02-08, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Postoji niz neodgovorenih pitanja o evolucijskom podrijetlu peroksisoma. Prije desetak godina provedena je filogenetska analiza peroksisomalnog proteoma u kojoj je otkriven minimalni ancestralni peroksisomalni proteom. Današnja velika količina genomskih podataka pruža idealne uvjete za analizu podrijetla ancestralnog peroksisomalnog proteoma. Kako bi se riješilo to pitanje, filogenetska stabla su napravljena za svaki protein u proteomu i nadopunjena su predikcijama sub-stanične lokalizacije i... More informacijama o proteinskim domenama s namjerom da se provede detaljna filogenetska analiza. Peroksini Pex1, Pex2, Pex4 i Pex10 imaju zajedničko podrijetlo s komponentama sustava ERAD, Pex5 s komponentama kompleksa koji promovira anafazu (engl. anaphase promoting complex) dok Pex14 nema evolucijsku povezanost s nijednim molekularnim sustavom. Pxa1 i Pxa2 koji imaju ulogu u transportu masnih kiselina imaju neovisno podrijetlo od odgovarajućih proteina u mitohondriju i staničnoj membrani. Dodavanje predstavnika nedavno sekvenciranih eukariotskih koljena i članova Asgard grupe ne mijenja postojeću filogeniju katalaze. Fox1 i Faa2 koji imaju ulogu u peroksisomalnoj β-oksidaciji masnih kiselina imaju neovisno podrijetlo od proteina koji sudjeluju u istom procesu smještenom u mitohondriju-dok Fox2 koji katalizira drugi korak oksidacije masnih kiselina ima podrijetlo iz mitohondrija. Less
Abstract (english)
There are a lot of unanswered questions about the evolutionary origin of the peroxisome. About ten years ago a phylogenetic analysis of peroxisomal proteome was conducted during which the minimal ancestral eukaryotic peroxisomal proteome was discovered. These days the larger amount of genomic data provides an ideal framework to analyze the origin of the ancestral peroxisome. To address this question, phylogenetic trees for each protein from the proteome were reconstructed and complemented... More with predictions of subcellular localization and protein domain information to perform a detailed phylogenetic analysis. Peroxins Pex1, Pex2, Pex4 and Pex10 show common origin with the components of ERAD, Pex5 with components of anaphase promoting complex/cyclosome (APC/C) while Pex14 doesn’t have evolutionary relationship with any molecular system. Pxa1 and Pxa2 that are involved in lipid transport show independent origin from its mitochondrial and cell membrane counterparts. Adding members from newly sequenced eukaryotic phyla and Asgard group didn’t change previously known phylogeny of catalase. Fox1 and Faa2 that are involved with peroxisomal β-oxidation show independent origin from the same process in mitochondria while Fox2 that catalyzes second step of β-oxidation is probably derived from mitochondria. Less
Keywords
Languagecroatian
URN:NBNurn:nbn:hr:217:704925
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-02-08
Terms of useLicence In copyright icon
Created on2019-04-02 10:45:35
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