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doctoral thesis
Genetic polymorphisms associated with the response to asthma treatment in children
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:586917
Banić, Ivana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Banić, I. (2019). Genetic polymorphisms associated with the response to asthma treatment in children (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:586917

Banić, Ivana. "Genetic polymorphisms associated with the response to asthma treatment in children." Doctoral thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:586917

Banić, Ivana. "Genetic polymorphisms associated with the response to asthma treatment in children." Doctoral thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:586917

Banić, I. (2019). 'Genetic polymorphisms associated with the response to asthma treatment in children', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 03 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:586917

Banić I. Genetic polymorphisms associated with the response to asthma treatment in children [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 May 03] Available at: https://urn.nsk.hr/urn:nbn:hr:217:586917

I. Banić, "Genetic polymorphisms associated with the response to asthma treatment in children", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:586917

Metadata
TitleGenetic polymorphisms associated with the response to asthma treatment in children
Title (croatian)Polimorfizmi gena povezanih s odgovorom na terapiju djece s astmom
AuthorIvana Banić
MentorMirjana Turkalj (mentor)
Committee memberKristian Vlahoviček (predsjednik povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2019-03-22, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Astma je najčešća kronična bolest u djece s trendom porasta prevalencije u budućnosti koju karakterizira izrazita heterogenost s obzirom na moguću etiologiju, stupanj upale i oštećenja bronha, poremećaj funkcije pluća i tijek bolesti. Astma se danas više ne smatra jedinstvenom bolešću nego sindromom s više različitih fenotipova definiranih novokoncipiranim imunopatoziološkim mehanizmima u kojem genska predispozicija igra važnu ulogu. Svrha ovog istraživanja je identificirati genske varijante povezane s učinkovitošću uobičajene terapije u astmi (inhalacijski kortikosteroidi, -agonisti i antagonisti leukotrienskih receptora) i specifične obrasce u odgovora na terapiju u astmi u djece (N= 365) te dati bolji uvid u patogenezu pojedinih podtipova bolesti. Rezultati ovog istraživanja pokazuju kako su određeni polimorfizmi u genima GLCCI1, TBX21, CRHR1, ADRB2 i MMP9 povezani s varijabilnim terapijskim ishodima te kako postoje diskretni obrasci terapijskih ishoda (pozitivni/ lošiji) povezani sa specifičnim fenotipskim karakteristikama poput razine i tipa upale, komorbiditeta i nekih genskih varijanti u djece s astmom.
Abstract (english)
Asthma is the most common chronic condition in children. It is characterized by high levels of heterogeneity in disease etiology, inflammation, bronchial and lung function impairment and natural course of the disease. Asthma is no longer considered a single disease but rather an „umbrella“ term encompassing several different phenotypes defined by newly conceived pathophysiologic mechanisms and genetic predisposition. The purpose of this research is to identify genetic variants associated with treatment success in asthma (inhaled corticosteroids, -agonists, leukotriene receptor antagonists) and specific treatment response patterns in children, providing better insight into the pathogenesis of specific disease subtypes. The results of this study indicate that certain polymorphisms in the GLCCI1, TBX21, CRHR1, ADRB2 and MMP9 genes are associated with variable treatment outcomes in asthmatic children and that there may be discrete treatment outcome patterns (good/poor) associated with specific phenotype characteristics such as inflammation level and type, comorbidity and certain genetic traits.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:586917
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-04-10 08:34:59