The research topic is scenario method from the spatial planning point of view and the main goal is building scenarios by combining quantitative and qualitative tools using the example of Southern Croatian Littoral/Dalmatia. The definition of spatial planning; theories, rationalities, and models of spatial planning; development and application of scenario method; specific procedures of scenario building and scenario types; examples of scenario application in research and planning at different spatial levels are all analysed. Factor analysis of 51 development indicators for 131 towns and municipalities in Dalmatia resulted in 6 key factors of recent development characteristics: 1. employment and generally dynamic economic activity; 2. negative birth-to-death rate and population ageing; 3. population concentration; 4. increase in population number and housing, with a significant share of vacation homes; 5. tourist development; 6. generally smaller economic activity, with orientation to primary and secondary sector of economic activity. Cluster analysis resulted in 5 types (clusters) of towns and municipalities in Dalmatia, corresponding to development characteristics. The qualitative part of the research encompassed the application of the Delphi method through two rounds of questionnaires. Based on the responses of 19 scientists and experts three explorative development scenarios for Dalmatia until 2031 were developed: ‘Monoculture of tourism’, ‘Sustainable tourism’, and ‘Integral development’. Implications for spatial planning of Dalmatia were listed. The research results show the importance of the application of scenario method principally in strategic spatial planning, and the advantages of combining quantitative and qualitative approaches in scenario construction. It was confirmed that scenario method in spatial planning of Dalmatia, besides trends and prediction of processes, needs to encompass implications or corrective measures, that are important not only to spatial planning, but also to a wider development context.