Autism is a neurodevelopmental disorder that falls under the Autistic spectre which encompasess other disorders like Rett syndrome, Aspergers syndrome, etc... The core symptoms of autistic disorder are: reduced social and communication abilities and repetative behaviour, interests and actions. The phenotype for autism is extremely variable and individual which makes understanding the patophysiology of the disorder difficult and complex. Throughout yeras of reasearch it has been established that many autism cases have a genetic cause. Specific genes have been identified which have an important role in neurodevelopment and in autism cases were shown to be dysfunctional. Furthermore, recent studies have shown the significance of epigenetics in autism reasearch. Epigenetic mechanisms such as DNA methylation or histone acetylation have been proven to influence gene expression of risk-factor genes for autism and expedite its development. Both genome and epigenome physiological pathways are intertwined and can influence the progress of autism development, but they can also influence each other in negative or positive ways. It is important to understand, all the identified genes, epigenetic changes, chemical imbalances and environmental factors work together and influence each other and neurodevelopment. As there is a significant amount of literature available on the topic, writing reviews summarizing all current data will be beneficial and will offer new perspective.