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master's thesis
Određivanje prazikvantela tekućinskom kromatografijom visoke djelotvornosti
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:447463
Tagliaretti, Petra
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Tagliaretti, P. (2019). Određivanje prazikvantela tekućinskom kromatografijom visoke djelotvornosti (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:447463

Tagliaretti, Petra. "Određivanje prazikvantela tekućinskom kromatografijom visoke djelotvornosti." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:447463

Tagliaretti, Petra. "Određivanje prazikvantela tekućinskom kromatografijom visoke djelotvornosti." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:447463

Tagliaretti, P. (2019). 'Određivanje prazikvantela tekućinskom kromatografijom visoke djelotvornosti', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:447463

Tagliaretti P. Određivanje prazikvantela tekućinskom kromatografijom visoke djelotvornosti [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:447463

P. Tagliaretti, "Određivanje prazikvantela tekućinskom kromatografijom visoke djelotvornosti", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:447463

Metadata
TitleOdređivanje prazikvantela tekućinskom kromatografijom visoke djelotvornosti
Title (english)Determination of praziquantelgy high performance liquid chromatography
AuthorPetra Tagliaretti
MentorNives Galić (mentor)
Committee memberNives Galić (predsjednik povjerenstva)
Committee memberInes Primožič (član povjerenstva)
Committee memberIvica Đilović (član povjerenstva)
Committee memberSnežana Miljanić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2019-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Prazikvantel (PZQ) je anthelmintik koji prema biofarmaceutskom sustavu klasifikacije spada u skupinu lijekova slabe topljivosti (skupina II). Međutim, utvrđeno je da mu se topljivost u biorelevantnom mediju povećava ukoliko je u kompleksu sa ciklodekstrinom. U ovom radu istražen je utjecaj β-ciklodekstrina i njegovih metil, sulfobutileter i hidroksipropil derivata na topljivost prazikvantela u vodenim otopinama. Također je ispitan utjecaj organskih kiselina (jabučna, jantarna, vinska i limunska) na poboljšanje topljivosti PZQ sa i bez prisutnosti ciklodekstrina. Koncentracija prazikvantela u vodenim otopinama određena je tekućinskom kromatografijom visoke djelotvornosti prethodno validiranom metodom za određivanje prazikvantela. Kompleksiranje prazikvantela ciklodekstrinima uzrokovalo je porast njegove topljivosti u vodi.
Abstract (english)
Praziquantel is an anthelminitic that is categorized in Biofarmaceutical Clasification System as a low solubility drug (BSC II class). However, studies have shown that its solubility in biorelevant medium increases with addition of cyclodextrin. In this thesis effect of β-cyclodextrin and its methyl, sulphobuthyleter and hydroxypropyl derivatives on solubility of praziquantel in aqueous solutions was studied. Improvement of solubility of PZQ with different organic acids (malic, succinic, tartaric and citric acid) with and without addition of cyclodextrins was studied as well. Validated high performance liquid chromatographic method was used for quantitative determination of PZQ in aqueous solutions. The solubility of PZQ in water was increased by complexation with cyclodextrines
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:447463
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-09-25
Terms of useLicence In copyright icon
Created on2019-09-27 08:35:12