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master's thesis
Diferencijalna analiza proteoma staničnih linija karcinoma pločastih stanica jezika Cal27 i Cal27-2B1
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:878567
Faraho, Ivan
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Faraho, I. (2015). Diferencijalna analiza proteoma staničnih linija karcinoma pločastih stanica jezika Cal27 i Cal27-2B1 (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:878567

Faraho, Ivan. "Diferencijalna analiza proteoma staničnih linija karcinoma pločastih stanica jezika Cal27 i Cal27-2B1." Master's thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:878567

Faraho, Ivan. "Diferencijalna analiza proteoma staničnih linija karcinoma pločastih stanica jezika Cal27 i Cal27-2B1." Master's thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:878567

Faraho, I. (2015). 'Diferencijalna analiza proteoma staničnih linija karcinoma pločastih stanica jezika Cal27 i Cal27-2B1', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:878567

Faraho I. Diferencijalna analiza proteoma staničnih linija karcinoma pločastih stanica jezika Cal27 i Cal27-2B1 [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:878567

I. Faraho, "Diferencijalna analiza proteoma staničnih linija karcinoma pločastih stanica jezika Cal27 i Cal27-2B1", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:878567

Metadata
TitleDiferencijalna analiza proteoma staničnih linija karcinoma pločastih stanica jezika Cal27 i Cal27-2B1
Title (english)Differential proteome analysis of of Cal27 and Cal27-2H1 human tonque
AuthorIvan Faraho
MentorMario Cindrić (mentor)
MentorAndreja Ambriović Ristov (mentor)
Committee memberBiljana Balen (predsjednik povjerenstva)
Committee memberGordana Lacković-Venturin (član povjerenstva)
Committee memberVesna Benković (član povjerenstva)
Committee memberKristian Vlahoviček (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2015-02-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Integrin v3 je transmembranski heterodimerni receptor koji posreduje u komunikaciji stanica s izvanstaničnim matriksom. Ima važnu ulogu u adheziji, proliferaciji, migraciji i preživljenju stanica, kao i otpornosti na citostatike. U radu je korištena stanična linija karcinoma pločastih stanica jezika čovjeka Cal27, te integrin 3-stabilno transficirani klon Cal27-2B1, koji de novo eksprimira integrin v3 na površini, te pokazuje povećanu ekspresiju integrina v5, smanjenu migraciju i povećanu otpornost na citostatike. Kako bi se dobio uvid u stanične mehanizme odgovorne za nastale promjene, diferencijalno su analizirani proteomi navedenih staničnih linija i identificirani su proteini kojima se razlikuju ekspresije u ovisnosti o ekspresiji integrina v3.
Abstract (english)
v3 integrin is a transmembrane heterodimeric receptor that mediate cell to cell and cell to ECM communication. It has an important role in adhesion, proliferation, migration and cell survival, as well as drug resistance. Focus of this research were human tongue squamous cell carcinoma cell line Cal27 and integrin 3 stably transfected clone Cal27-2B1, with de novo expression of integrin v3, overexpression of integrin v5, decreased cell migration and increased drug resistance. Proteomes of these cell lines were differentialy analized to get an insight into mechanisms responsible for observed changes, and proteins with different expressions depending on integrin v3 expression were identified.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:878567
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-21 09:55:54