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master's thesis
Analiza krema i masti nepoznatog sastava
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:204933
Petrušić, Vida
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Petrušić, V. (2019). Analiza krema i masti nepoznatog sastava (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:204933

Petrušić, Vida. "Analiza krema i masti nepoznatog sastava." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:204933

Petrušić, Vida. "Analiza krema i masti nepoznatog sastava." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:204933

Petrušić, V. (2019). 'Analiza krema i masti nepoznatog sastava', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:204933

Petrušić V. Analiza krema i masti nepoznatog sastava [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:204933

V. Petrušić, "Analiza krema i masti nepoznatog sastava", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:204933

Metadata
TitleAnaliza krema i masti nepoznatog sastava
Title (english)Analysis of ointments and creams of unknown composition
AuthorVida Petrušić
MentorPredrag Novak (mentor)
Committee memberPredrag Novak (predsjednik povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberInes Primožič (član povjerenstva)
Committee memberIvica Đilović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2019-02-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U ovom radu su za određivanje sastava uzoraka krema i masti indicirane za liječenje psorijaze primjenjene vibracijska spektroskopija, tekućinska kromatografija visoke djelotvornosti i spektrofotometrija u ultraljubičastom i vidljivom području. Na temelju analize snimljenih spektara IR u uzorku kreme 1 potvrđena je prisutnost kortikosteroida kao aktivne tvari, a u uzorku 2 prisutnost salicilne kiseline. Na temelju usporedbe spektara i asignacije identificirane su nosive tvari u oba uzorka, belobaza za uzorak 1 i vazelin za uzorak 2. Nadalje, korištenjem tekućinske kromatografije visoke djelotvornosti određena su retencijska vremena aktivnih komponenti komercijalnih masti i krema. Usporedba kromatograma uzoraka 1 i 2, upućuje na prisutnost kortikosteroida betametazona u uzorku 1, dok je za uzorak 2 potvrđena prisutnost salicilne kiseline. Spektri LC-MS potvrdili su navedene spojeve u uzorcima. Otapanjem matrica vazelina i belobaze u propan˗1˗ol-u napravljeni su preliminarni baždarni dijagrami sa ciljem mogućnosti kvantitativnog određivanja količine matrica u uzorku.
Abstract (english)
Vibrational and UV spectroscopies and high performance liquid chromatography (HPLC) have been used to determine active components in ointment and cream samples. On the basis of IR spectral analysis the presence of corticosteroids has been detected in the sample 1 while salicylic acid has been found in the sample 2. Furthermore, belobase matrix has been detected in the sample 1 and vaseline in the sample 2. These findings have been confirmed by the HPLC and LC-MS analyses which revealed betamethasone as the active compound in the sample 1 and salicylic acid in the sample 2. By using UV spectroscopy in propan˗1˗ol calibration diagram for quantitative determination of matrices have been constructed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:204933
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-10-03 12:14:28