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undergraduate thesis
Evolucija tumora
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:047522
Tudor, Matko
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Tudor, M. (2019). Evolucija tumora (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:047522

Tudor, Matko. "Evolucija tumora." Undergraduate thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:047522

Tudor, Matko. "Evolucija tumora." Undergraduate thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:047522

Tudor, M. (2019). 'Evolucija tumora', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 04 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:047522

Tudor M. Evolucija tumora [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 December 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:047522

M. Tudor, "Evolucija tumora", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:047522

Metadata
TitleEvolucija tumora
Title (english)Tumor evolution
AuthorMatko Tudor
MentorMaja Matulić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2019, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Tumori su nenormalna nakupina stanica koja nastaje proliferacijom stanice te nakupljanjem pogodnih genomskih promjena. Takva stanica prestaje surađivati sa stanicama u održavanju homeostaze. Tumorska populacija je heterogena te je sastav stanica varijabilan koja u ovisnosti o mikrookolišu. Stanice sa pogodnim fenotipom preživljavaju te stvaraju subklonske populacije, dok neprilagođene stanice te njihove subklonske populacije izumiru. Također, tumorske stanice mogu imati različite fenotipe koji im omogućavaju preživljavanje i proliferaciju u konstantno promjenjivim uvjetima. Sama heterogenost tumora posljedica je izdašnih genomskih promjena; mutacije gena i epigenetske promjene dovode do spore evolucije koju, u nekim tipovima tumora, prekidaju katastrofični događaji koji dovode do promjene kariotipa svake pojedine stanice, što u veoma kratkome roku još i više povećava heterogenost populacije, tj. ubrzava evoluciju. Tumorske stanice su u kooperaciji sa ostalim tumorskim stanicama, ali i u interakciji sa normalnim stanicama. Tumori mijenjaju svoj mikrookoliš na način da utječu na normalne stanice produktima metabolizma ili putem signalnih molekula. Mijenjanje okoliša uključuje promjene normalnih stanica ali i degradaciju vanstaničnog matriksa. Progresija tumora završava smrću organizma, što je posljedica metastaza. Metastaze su kompleksan proces pri kojemu stanice napuštaju tumor te koloniziraju udaljena tkiva. Stanice sposobne za metastaze su preadaptirane u primarnom tumoru te imaju posebne prilagodbe koje im omogućuju preživljavanje i proliferaciju u udaljenim tkivima.
Abstract (english)
Tumors are abnormal clusters of cells that arise when a cell acquires advantageous set of mutations that cause abnormal proliferation and evading cell death. Tumor populations are heterogeneous clusters with variable cell composition according to changes in microenvironment. Cells with suitable phenotype survive, divide and give rise to subclonal populations, while cells that do not have suitable phenotype go extinct. Furthermore, some tumor cells show phenotypes that allow them to survive and proliferate in constantly changing microenvironment. Heterogeneity is a result of various genomic changes. Gene mutations and epigenetic changes lead to gradual evolution, while chromosomal changes lead to punctuated evolution. Also, tumor cells are in constant cooperation with other tumor and normal cells. Tumor cells change their environment, including other cells and extracellular matrix, with products of metabolism or with various signaling molecules. Tumor progression leads to metastasis that eventually kill the host. Metastasis are a complex process by which tumor cells colonize distant tissues. Cells capable of colonizing distant tissues are pre-adapted to microenvironment in distant tissue.
Keywords
Languagecroatian
URN:NBNurn:nbn:hr:217:047522
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-10-09 11:06:51