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undergraduate thesis
Epigenetski mehanizmi u razvoju sisavaca
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:034551
Dudaš, Ana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Dudaš, A. (2019). Epigenetski mehanizmi u razvoju sisavaca (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:034551

Dudaš, Ana. "Epigenetski mehanizmi u razvoju sisavaca." Undergraduate thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:034551

Dudaš, Ana. "Epigenetski mehanizmi u razvoju sisavaca." Undergraduate thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:034551

Dudaš, A. (2019). 'Epigenetski mehanizmi u razvoju sisavaca', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:034551

Dudaš A. Epigenetski mehanizmi u razvoju sisavaca [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:034551

A. Dudaš, "Epigenetski mehanizmi u razvoju sisavaca", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:034551

Metadata
TitleEpigenetski mehanizmi u razvoju sisavaca
Title (english)Epigenetic mechanisms in mammalian development
AuthorAna Dudaš
MentorRomana Gračan (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2019, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Metilacija DNA jedan je od izrazito važnih procesa u razvoju sisavaca te u diferencijaciji matičnih stanica koje se tako, poprimajući specifičan ekspresijski obrazac zahvaljujući epigenetskim modifikacijama njihovih genoma, usmjeravaju u točno određeni tip stanica sa specifičnom funkcijom te se sprječava njihovo vraćanje u nediferencirano stanje. Brojni enzimi sudjeluju u uspostavljanju metilacijskih oznaka u DNA te su također otkriveni oni koji pomažu u uklanjanju takvih oznaka. Naime, upravo je uklanjanje metilacijskih oznaka važno za pravilan razvoj predimplantacijskog embrija budući da se tada odvija veliki val epigenetskog reprogramiranja u kojemu se uklanjaju epigenetske oznake s roditeljskih genoma, koji pritom slijede različite mehanizme demetilacije, te se uspostavlja pluripotentno stanje stanica koje će potom omogućiti njihovu diferencijaciju. Razvitak tehnika sekvenciranja i analize epigenoma u pojedinim stadijima ranog embrionalnog razvitka omogućili su veće razumijevanje epigenetskog reprogramiranja u razvoju sisavaca te su dosadašnja saznanja o istom predstavljena u ovom radu.
Abstract (english)
DNA methylation is one of extremely important processes in mammalian development and in differentiation of the stem cells which are, by establishing specific expression pattern thanks to epigenetic modifications of their genomes, directed in determined cell type with specific function and their return to undifferentiated condition is prohibited. Numerous enzymes are involved in DNA methylation and the ones that help in removing methylation were also discovered. The removal of methylation is important for regular development of preimplantation embryo, since a big wave of epigenetic reprogramming takes place then which enables removal of epigenetic marks from parental genomes, that undergo different mechanisms of demethylation, and establishment of pluripotency in the cells which are going to differentiate later. Developing of sequencing techniques and epigenome analysis in certain stages of early embryonal development have enabled greater understanding of epigenetic reprogramming in mammalian development and knowledges about it so far are presented in this paper.
Keywords
Languagecroatian
URN:NBNurn:nbn:hr:217:034551
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-10-09 11:31:36