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undergraduate thesis
Polarizacija makrofaga u zdravlju i bolesti
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:981871
Horvat, Marina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Horvat, M. (2019). Polarizacija makrofaga u zdravlju i bolesti (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:981871

Horvat, Marina. "Polarizacija makrofaga u zdravlju i bolesti." Undergraduate thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:981871

Horvat, Marina. "Polarizacija makrofaga u zdravlju i bolesti." Undergraduate thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:981871

Horvat, M. (2019). 'Polarizacija makrofaga u zdravlju i bolesti', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:981871

Horvat M. Polarizacija makrofaga u zdravlju i bolesti [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:981871

M. Horvat, "Polarizacija makrofaga u zdravlju i bolesti", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:981871

Metadata
TitlePolarizacija makrofaga u zdravlju i bolesti
Title (english)Macrophage polarization in health and disease
AuthorMarina Horvat
MentorNada Oršolić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2019, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Makrofagi imaju temeljnu ulogu u održavanju homeostaze tkiva i obrani organizma od patogena. Različita tkivna mikrookruženja, kao i njihove patološke promjene, mogu duboko utjecati na polarizacijsko stanje makrofaga prema ekstremnim fenotipovima M1 (proupalnom) i M2 (protuupalnom), kako bi se javio najprikladniji tip i intenzitet imunosnog odgovora. Međutim, u ovom radu prikazana je njihova tendencija zauzimanja istaknutih uloga u uspostavi i razvoju tumora, virusnoj infekciji te bolesti, upalnih i metaboličkih, koje danas imaju velik negativan učinak na čovječanstvo. Stoga bi razumijevanje funkcionalne raznolikosti ovih stanica u zdravlju i bolesti, kao i mehanizama koji kontroliraju te događaje, bilo ključno za osmišljavanje strategija za reguliranje tih bolesti i ponovno uspostavljanje homeostaze.
Abstract (english)
Macrophages have a fundamental role in maintaining tissue homeostasis and defence against pathogens. Different tissue microenvironments, as well as their pathological alterations, can have a profound influence on the polarization state of macrophages towards extreme M1 (proinflammatory) and M2 (antiinflammatory) phenotypes, to provide the most appropriate type and intensity of the immune response. However, this paper demonstrates their tendency to occupy prominent roles in the establishment and development of tumors, viral infections and diseases, inflammatory and metabolic, which today have a great negative impact on humanity. Therefore, understanding the functional diversity of these cells in health and illness, as well as the mechanisms that control these events, is crucial to design strategies for regulating these diseases and re-establishing homeostasis.
Keywords
Languagecroatian
URN:NBNurn:nbn:hr:217:981871
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2019-10-10 08:05:28