Oxidative stress is a disturbance in the balance of oxidation-reduction processes in an organism, where the shift of equilibrium is directed to oxidation. This disorder results in excessive production of free radicals of oxygen and insufficient activity of the antioxidant system. The role of the radicals is defined in the pathogenesis of numerous diseases, including osteoporosis. This paper explores the effect of chrysin in the treatment of osteoporosis induced by intragastric application of retinoic acid (13cRA) in rats at a dose of 80 mg kg-1 for 14 days. Chrysin (100 mg kg-1) or alendronate (40 mg kg-1) as a positive control was applied for 14 days.The effectiveness of chrysin in the treatment of osteoporosis wasmonitored bythe change in mass of experimental animals, weight, length and diameter of the femur, the content of calcium and phosphorus, and bone mineral density as well as biochemical and hematological determinants. The antioxidant capacity of chrysin we estimated by measuring the levels of lipid peroxidation, glutathione and catalase enzyme activity and superodsid dismutase in the liver tissue, kidney, and spleen, as the genotoxic effects analysis of blood micronucleus and comet assay. The results indicate that chrysin has significant antioxidant, antiimmflamatory and antiosteoporotic activity, and that its application could be used to prevent osteoporosis. Easy accessibility, cost-effectiveness and lack of toxicity indicate that chrysin has an advantage over alendronate.