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master's thesis
Polimorfizmi gena NAT1 i NAT2 u romskim populacijama Hrvatske
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:809550
Škobalj, Marko
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Škobalj, M. (2019). Polimorfizmi gena NAT1 i NAT2 u romskim populacijama Hrvatske (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:809550

Škobalj, Marko. "Polimorfizmi gena NAT1 i NAT2 u romskim populacijama Hrvatske." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:809550

Škobalj, Marko. "Polimorfizmi gena NAT1 i NAT2 u romskim populacijama Hrvatske." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:809550

Škobalj, M. (2019). 'Polimorfizmi gena NAT1 i NAT2 u romskim populacijama Hrvatske', Master's thesis, University of Zagreb, Faculty of Science, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:809550

Škobalj M. Polimorfizmi gena NAT1 i NAT2 u romskim populacijama Hrvatske [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:217:809550

M. Škobalj, "Polimorfizmi gena NAT1 i NAT2 u romskim populacijama Hrvatske", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:809550

Metadata
TitlePolimorfizmi gena NAT1 i NAT2 u romskim populacijama Hrvatske
Title (english)Polymorphismso of NAT1 and NAT2 genes in Croatian Roma populations
AuthorMarko Škobalj
MentorMarijana Peričić Salihović (mentor)
Committee memberDamjan Franjević (predsjednik povjerenstva)
Committee memberDomagoj Đikić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2019, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Romi su transnacionalna manjinska populacija koja je zbog svojih osobitosti uspjela u velikoj mjeri sve do danas sačuvati svoju izoliranost koja utječe na njihovu zalihu gena. U ovom radu analizirana je varijabilnost gena NAT1 i NAT2 koji sudjeluju u metabolizmu brojnih lijekova i ksenobiotika, kod 439 pripadnika populacija Roma, od kojih su 177 s područja Balkana, 132 s područja Baranje i 130 s područja Međimurja. Cilj je bio utvrditi kako genetička povijest populacija, migracije i endogamija utječu na raspodjelu alela i haplotipova u istraživanim genima. Od 7 analiziranih lokusa gena NAT1 3 su bila polimorfna, a od 6 analiziranih lokusa gena NAT2 5 ih je bilo polimorfno. Svi polimorfni lokusi bili su u Hardy-Weinbergovoj ravnoteži. Raspodjela rekonstruiranih haplotipova gena NAT1 nije pokazivala populacijsku različitost, dok je u raspodjeli haplotipova gena NAT2 uočen haplotip specifičan samo za populaciju Roma iz Baranje. Interpopulacijske metode utvrdile su veću različitost između populacija kod gena NAT2 nego kod gena NAT1, kao što su i genetičke udaljenosti između romskih populacija također bile izraženije kod gena NAT2. Sveukupna veća raznolikost istraživanih lokusa kod gena NAT2 nego kod gena NAT1 u skladu je s njihovim evolucijskim obrascima.
Abstract (english)
The Roma are a transnational minority population which, due to its characteristics, has largely managed to maintain its isolation, which affects their gene pool. This thesis has analyzed the variability of NAT1 and NAT2 genes involved in metabolism of numerous drugs and xenobiotics in 439 members of the Roma people, including 177 from the Balkans, 132 from Baranja and 130 from Međimurje. The aim was to determine how the populations' genetic history, migration, and endogamy affect the distribution of alleles and haplotypes in the genes studied. Of the 7 analyzed NAT1 gene loci three were polymorphic, and of the 6 analyzed NAT2 gene loci five were polymorphic. All polymorphic loci were in Hardy- Weinberg equilibrium. The distribution of reconstructed NAT1 gene haplotypes did not show population diversity, whereas in the distribution of NAT2 haplotypes a haplotype specific only to the Roma population from Baranja was observed. Interpopulation methods found greater diversity between populations in the NAT2 gene than in the NAT1 gene, as genetic distances between Roma populations were also more pronounced in the NAT2 gene. The overall greater diversity of the loci studied in the NAT2 gene than in the NAT1 gene is consistent with their evolutionary patterns
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:809550
Study programmeTitle: Biology; specializations in: Ecology
Course: Ecology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra biologije (magistar/magistra biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-09-19
Terms of useLicence In copyright icon
Created on2019-10-23 12:05:57