prikaz prve stranice dokumenta Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus)
  Download
PDF 904.38 KB
master's thesis
Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus)
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:821696
Pavlinec, Željko
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Pavlinec, Ž. (2014). Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus) (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:821696

Pavlinec, Željko. "Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus)." Master's thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:821696

Pavlinec, Željko. "Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus)." Master's thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:821696

Pavlinec, Ž. (2014). 'Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus)', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:821696

Pavlinec Ž. Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus) [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:821696

Ž. Pavlinec, "Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus)", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:821696

Metadata
TitleRaznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u plavobijelog dupina (Stenella coeruleoalba) i glavatog dupina (Grampus griseus)
Title (english)Variability of major histocompatibility complex DQA and DQB class II genes in the striped dolphin (Stenella coeruleoalba) and Risso's dolphin (Grampus griseus)
AuthorŽeljko Pavlinec
MentorAna Galov (mentor)
MentorMartina Đuras (mentor)
Committee memberAna Galov (predsjednik povjerenstva)
Committee memberDamjan Franjević (član povjerenstva)
Committee memberZlatko Liber (član povjerenstva)
Committee memberInga Marijanović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014-07-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Glavni sustav tkivne podudarnosti (MHC) ima središnju imunoregulacijsku ulogu. Raznolikost MHC-a je bitna za preživljavanje vrste jer omogućava prepoznavanje širokog spektra patogena. Ta raznolikost je nastala pod utjecajem selekcije, pa MHC geni služe kao biljezi za proučavanje adaptivne evolucije populacija i vrsta. Plavobijeli dupin (Stenella coeruleoalba) i glavati dupin (Grampus griseus) pripadaju porodici Delphinidae, podred Odontoceti, red Cetacea. Obje vrste nastanjuju topla i umjereno topla mora i to uglavnom pučinske dijelove. Cilj istraživanja bio je odrediti razinu raznolikosti gena DQA i DQB skupine II MHC sustava plavobijelog i glavatog dupina. U uzorcima tkiva 24 jedinke plavobijelog i osam jedinki glavatog dupina iz Sredozemnog mora pronađen je ukupno 21 alel na DQA lokusu i 21 alel na DQB lokusu, od kojih su samo tri DQA alela poznata iz prethodnih istraživanja. Broj jedinstvenih alela, kao i evolucijske udaljenosti ukazuju na visok stupanj raznolikosti u obje vrste, dok omjer stopa nesinonimnih i sinonimnih supstitucija potvrđuje pretpostavku da je raznolikost na istraživanim lokusima održavana pozitivnom selekcijom.
Abstract (english)
Major histocompatibility system (MHC) has a central role in the regulation of immune response. MHC diversity is essential for the survival of the species because it allows for the recognition of a wide spectrum of pathogens. That diversity evolved under selective pressure, so MHC genes can be used as markers for the study of adaptive evolution in populations or species. Striped dolphin (Stenella coeruleoalba) and Risso’s dolphin (Grampus griseus) are a part of the family Delphinidae, suborder Odontoceti, order Cetacea. Both species inhabit pelagic warm and temperate waters. The goal of this study was to determine the variability of MHC class II DQA and DQB genes in the striped dolphin and Risso’s dolphin. In tissue samples from 21 striped and eight Risso’s dolphins a total of 21 DQA and 21 DQB alleles were found, of which only three DQA alleles were known from previous studies. The number of unique alleles, as well as the calculated evolutionary distances show a high level of diversity in both species, while the rates of non-synonymous and synonymous substitutions indicate the maintenance of the diversity on both loci by positive selection.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:821696
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-24 11:52:34