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master's thesis
Povezanost monoaminoksidaze tipa B i trauma u djetinjstvu s posttraumatskim stresnim poremećajem
Zagreb: University of Zagreb, Faculty of Science, 2019. urn:nbn:hr:217:713114
Marin, Nika
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Marin, N. (2019). Povezanost monoaminoksidaze tipa B i trauma u djetinjstvu s posttraumatskim stresnim poremećajem (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:713114

Marin, Nika. "Povezanost monoaminoksidaze tipa B i trauma u djetinjstvu s posttraumatskim stresnim poremećajem." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:713114

Marin, Nika. "Povezanost monoaminoksidaze tipa B i trauma u djetinjstvu s posttraumatskim stresnim poremećajem." Master's thesis, University of Zagreb, Faculty of Science, 2019. https://urn.nsk.hr/urn:nbn:hr:217:713114

Marin, N. (2019). 'Povezanost monoaminoksidaze tipa B i trauma u djetinjstvu s posttraumatskim stresnim poremećajem', Master's thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:713114

Marin N. Povezanost monoaminoksidaze tipa B i trauma u djetinjstvu s posttraumatskim stresnim poremećajem [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2019 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:713114

N. Marin, "Povezanost monoaminoksidaze tipa B i trauma u djetinjstvu s posttraumatskim stresnim poremećajem", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:217:713114

Metadata
TitlePovezanost monoaminoksidaze tipa B i trauma u djetinjstvu s posttraumatskim stresnim poremećajem
Title (english)Association of monoamino oxidase B and childhood trauma with post-traumatic stress disorder
AuthorNika Marin
MentorDubravka Švob Štrac (mentor)
MentorJulija Erhardt (mentor)
Committee memberJulija Erhardt (predsjednik povjerenstva)
Committee memberIvana Ivančić Baće (član povjerenstva)
Committee memberDamjan Franjević (član povjerenstva)
Committee memberSofia Ana Blažević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2019-09-30, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Monoaminooksidaza (MAO) razgrađuje biogene amine, uključujući neurotransmitore dopamin, histamin, serotonin i noradrenalin. Uloga ovog enzima u regulaciji raspoloženja, emocija i ponašanja upućuje na uključenost u patofiziologiju raznih neuropsihijatrijskih poremećaja. Kako trombociti i neuroni dijele brojne biokemijske procese, aktivnost trombocitne MAO-B može poslužiti kao periferni pokazatelj određenih promjena ponašanja i osobnosti. Posttraumatski stresni poremećaj (PTSP) je kompleksan psihijatrijski poremećaj koji nastaje nakon izlaganja traumatskom iskustvu, sa nepotpuno jasnom neurobiološkom podlogom. Istraživanja upućuju da su u razvoj i težinu simptoma PTSP-a uključene promjene neurotransmitorskih sustava, za koje su djelomično odgovorne i varijacije određenih gena, ali i okolišni čimbenici poput traume u djetinjstvu. Stoga je cilj istraživanja bio istražiti povezanost polimorfizama gena MAOB, aktivnosti trombocitne MAO-B, te traume u djetinjstvu, s razvojem i težinom simptoma PTSP-a u hrvatskih ispitanika. Značajne razlike u aktivnosti trombocitne MAO-B pronađene su između kontrolnih ispitanika i ratnih veterana s PTSP-om, te između bolesnika sa srednjim i teškim PTSP-om. Također je utvrđena povezanost gena MAOB s razvojem PTSP-a, kao i traumatskih događaja u djetinjstvu s težinom simptoma PTSP-a, te značajna interakcija polimorfizma rs1799836 gena MAOB i fizičkog zanemarivanja u djetinjstvu. Međutim, u svrhu razjašnjavanja uloge genetskih i okolišnih čimbenika, te njihovih kompleksnih interakcija u PTSP-u, potrebna su daljnja istraživanja.
Abstract (english)
Monoamine oxidase (MAO) degrades biogenic amines, including neurotransmitters dopamine, histamine, serotonin and noradrenaline. The role of this enzyme in the regulation of mood, emotions and behavior suggest its involvement in the pathophysiology of various neuropsychiatric disorders. As platelets and neurons share numerous biochemical processes, platelet MAO-B activity might serve as peripheral marker of certain behavioral and personality changes. Post-traumatic stress disorder (PTSD) is complex psychiatric disorder developing after traumatic experience, with unclear neurobiological background. Research suggests that development and severity of PTSD symptoms include changes in neurotransmitter systems, partly due to certain gene variations, but also environmental factors such as childhood trauma. The study investigated associations of MAOB gene polymorphisms, platelet MAO-B activity, and childhood trauma, with development and severity of PTSD symptoms in Croatian subjects. Differences in platelet MAO-B activity were found between subjects with and without PTSD, and between patients with moderate and severe PTSD. Results demonstrated association between MAOB gene and development of PTSD, between childhood trauma and severity of PTSD symptoms; as well as significant interaction of rs1799836 MAOB gene polymorphism and physical neglect in childhood. However, further research is necessary to clarify the role of genetic and environmental factors and their complex interactions in PTSD.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:713114
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-09-30
Terms of useLicence In copyright icon
Created on2019-11-19 09:53:17