prikaz prve stranice dokumenta Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I
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Scientific paper - Original scientific paper
Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I
Scientific Reports, 6 (2016); 25736. https://doi.org/10.1038/srep25736
Cojoc, Gheorghe; Ana-Maria, Florescu; Krull, Alexander; Anna H., Klemm; Pavin, Nenad; Jülicher, Frank; Tolić, Iva Marija

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Cojoc, G., Ana Maria, F., Krull, A., Anna H., K., Pavin, N., Jülicher, F. & Tolić, I. M. (2016). Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I. Scientific Reports, 6.. doi: 10.1038/srep25736

Cojoc, Gheorghe, et al. "Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I." Scientific Reports, vol. 6, 2016. https://doi.org/10.1038/srep25736

Cojoc, Gheorghe, Florescu Ana Maria, Alexander Krull, Klemm Anna H., Nenad Pavin, Frank Jülicher and Iva Marija Tolić. "Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I." Scientific Reports 6 (2016). https://doi.org/10.1038/srep25736

Cojoc, G., et al. (2016) 'Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I', Scientific Reports, 6. doi: 10.1038/srep25736

Cojoc G, Ana Maria F, Krull A, Anna H. K, Pavin N, Jülicher F, and sur.. Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I. Scientific Reports [Internet]. 2016 [cited 2024 December 29];6. doi: 10.1038/srep25736

G. Cojoc, et al., "Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I", Scientific Reports, vol. 6, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:824945. [Accessed: 29 December 2024]

Metadata
Title (english)Paired arrangement of kinetochores together with microtubule pivoting and dynamics drive kinetochore capture in meiosis I
AuthorGheorghe Cojoc
AuthorFlorescu Ana-Maria
AuthorAlexander Krull
AuthorKlemm Anna H.
AuthorNenad Pavin
MBZ: 204800
AuthorFrank Jülicher
AuthorIva Marija Tolić
MBZ: 260543
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract (english)
Kinetochores are protein complexes on the chromosomes, whose function as linkers between spindle microtubules and chromosomes is crucial for proper cell division. The mechanisms that facilitate kinetochore capture by microtubules are still unclear. In the present study, we combine experiments and theory to explore the mechanisms of kinetochore capture at the onset of meiosis I in fission yeast. We show that kinetochores on homologous chromosomes move together, microtubules are dynamic and pivot around the spindle pole, and the average capture time is 3-4 minutes. Our theory describes paired kinetochores on homologous chromosomes as a single object, as well as angular movement of microtubules and their dynamics. For the experimentally measured parameters, the model reproduces the measured capture kinetics and shows that the paired configuration of kinetochores accelerates capture, whereas microtubule pivoting and dynamics have a smaller contribution. Kinetochore pairing may be a general feature that increases capture efficiency in meiotic cells.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 6, 25736
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/srep25736
URN:NBNurn:nbn:hr:217:824945
Publication2016
Document URLhttps://www.nature.com/articles/srep25736
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Public note© The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/. Received: 28 January 2016. Accepted: 21 April 2016. Published: 11 May 2016.
Created on2020-02-23 14:37:35