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Scientific paper - Original scientific paper
Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells
Frontiers in Genetics, 9 (2018); 296. https://doi.org/10.3389/fgene.2018.00296
Jelenić, Ivan; Selmecki, Anna; Laan, Liedewij; Pavin, Nenad

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Jelenić, I., Selmecki, A., Laan, L. & Pavin, N. (2018). Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells. Frontiers in Genetics, 9.. doi: 10.3389/fgene.2018.00296

Jelenić, Ivan, et al. "Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells." Frontiers in Genetics, vol. 9, 2018. https://doi.org/10.3389/fgene.2018.00296

Jelenić, Ivan, Anna Selmecki, Liedewij Laan and Nenad Pavin. "Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells." Frontiers in Genetics 9 (2018). https://doi.org/10.3389/fgene.2018.00296

Jelenić, I., et al. (2018) 'Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells', Frontiers in Genetics, 9. doi: 10.3389/fgene.2018.00296

Jelenić I, Selmecki A, Laan L, Pavin N. Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells. Frontiers in Genetics [Internet]. 2018 [cited 2024 December 21];9. doi: 10.3389/fgene.2018.00296

I. Jelenić, A. Selmecki, L. Laan and N. Pavin, "Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells", Frontiers in Genetics, vol. 9, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:901575. [Accessed: 21 December 2024]

Metadata
Title (english)Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells
AuthorIvan Jelenić
AuthorAnna Selmecki
AuthorLiedewij Laan
AuthorNenad Pavin
MBZ: 204800
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Interdisciplinary Natural Sciences
Abstract (english)
Faithful chromosome segregation, driven by the mitotic spindle, is essential for organismal survival. Neopolyploid cells from diverse species exhibit a significant increase in mitotic errors relative to their diploid progenitors, resulting in chromosome nondisjunction. In the model system Saccharomyces cerevisiae, the rate of chromosome loss in haploid and diploid cells is measured to be one thousand times lower than the rate of loss in isogenic tetraploid cells. Currently it is unknown what constrains the number of chromosomes that can be segregated with high fidelity in an organism. Here we developed a simple mathematical model to study how different rates of chromosome loss in cells with different ploidy can arise from changes in (1) spindle dynamics and (2) a maximum duration of mitotic arrest, after which cells enter anaphase. We apply this model to S. cerevisiae to show that this model can explain the observed rates of chromosome loss in S. cerevisiae cells of different ploidy. Our model describes how small increases in spindle assembly time can result in dramatic differences in the rate of chromosomes loss between cells of increasing ploidy and predicts the maximum duration of mitotic arrest.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Genetics
Numberingvol. 9, 296
p-ISSN1664-8021
DOIhttps://doi.org/10.3389/fgene.2018.00296
URN:NBNurn:nbn:hr:217:901575
Publication2018
Document URLhttps://www.frontiersin.org/articles/10.3389/fgene.2018.00296/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Public noteCopyright © 2018 Jelenić, Selmecki, Laan and Pavin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Received: 02 March 2018. Accepted: 13 July 2018. Published: 06 August 2018.
Created on2020-03-01 11:41:16