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master's thesis
Priprava i karakterizacija benzil-, benzo-3,4-(1,3-dioksolil)-, metiltiofen-2-karboksilat-3-il-, 2-naftil i p-trifluormetoksifenil- makrozona, novih konjugata makrolidnih antibiotika
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:240827
Facković, Matea
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Facković, M. (2020). Priprava i karakterizacija benzil-, benzo-3,4-(1,3-dioksolil)-, metiltiofen-2-karboksilat-3-il-, 2-naftil i p-trifluormetoksifenil- makrozona, novih konjugata makrolidnih antibiotika (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:240827

Facković, Matea. "Priprava i karakterizacija benzil-, benzo-3,4-(1,3-dioksolil)-, metiltiofen-2-karboksilat-3-il-, 2-naftil i p-trifluormetoksifenil- makrozona, novih konjugata makrolidnih antibiotika." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:240827

Facković, Matea. "Priprava i karakterizacija benzil-, benzo-3,4-(1,3-dioksolil)-, metiltiofen-2-karboksilat-3-il-, 2-naftil i p-trifluormetoksifenil- makrozona, novih konjugata makrolidnih antibiotika." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:240827

Facković, M. (2020). 'Priprava i karakterizacija benzil-, benzo-3,4-(1,3-dioksolil)-, metiltiofen-2-karboksilat-3-il-, 2-naftil i p-trifluormetoksifenil- makrozona, novih konjugata makrolidnih antibiotika', Master's thesis, University of Zagreb, Faculty of Science, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:240827

Facković M. Priprava i karakterizacija benzil-, benzo-3,4-(1,3-dioksolil)-, metiltiofen-2-karboksilat-3-il-, 2-naftil i p-trifluormetoksifenil- makrozona, novih konjugata makrolidnih antibiotika [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:217:240827

M. Facković, "Priprava i karakterizacija benzil-, benzo-3,4-(1,3-dioksolil)-, metiltiofen-2-karboksilat-3-il-, 2-naftil i p-trifluormetoksifenil- makrozona, novih konjugata makrolidnih antibiotika", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:240827

Metadata
TitlePriprava i karakterizacija benzil-, benzo-3,4-(1,3-dioksolil)-, metiltiofen-2-karboksilat-3-il-, 2-naftil i p-trifluormetoksifenil- makrozona, novih konjugata makrolidnih antibiotika
Title (english)Preparation and characterization of a benzyl-, benzo-3,4-(1,3-dioxolyl)-, methyl-thiophene-2-carboxylate-3-yl, 2-naphthyl-, and p-trifluoromethoxy-phenyl-macrozone, new conjugates of macrolide antibiotics
AuthorMatea Facković
MentorPredrag Novak (mentor)
Committee memberPredrag Novak (predsjednik povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberVesna Petrović Peroković (član povjerenstva)
Committee memberIvana Biljan (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2020-02-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Makrolidni antibiotici, kao što je azitromicin, imaju široku primjenu u liječenju infekcija dišnih puteva. Djeluju kao inhibitori sinteze proteina vežući se na bakterijsku ribosomsku podjedinicu 50S. Zbog povećane rezistencije bakterija javlja se potreba za razvojem novih, poboljšanih antibiotika. Dobru antibakterijsku aktivnost in vitro na odabrane Gram-pozitivne i Gram-negativne bakterije pokazuju makrozoni, novi konjugati azitromicina i tiosemikarbazida. Konjugacijom 9a-(γ-aminopropil) derivata azitromicina i novosintetiziranih tiosemikarbazida e1-e5 pripravljeno je pet novih spojeva, f1-f5. Sintetizirani spojevi pročišćeni su kolonskom kromatografijom, a struktura im je određena na temelju snimljenih jedno- i dvodimenzijskih spektara NMR te spektara MS. Budućim istraživanjima ispitat će se biološka aktivnost pripravljenih spojeva.
Abstract (english)
Macrolide antibiotics, such as azithromycin, have been widely prescribed for the treatment of respiratory tract infections. They act as inhibitors of protein synthesis by binding to the bacterial ribosomal subunit 50S. Drug resistant microbial pathogens today represent a serious global problem that requires the discovery of new and more effective antimicrobial agents. Macrozones are novel conjugates of azithromycin and thiosemicarbazides that shows very good antibacterial activity. Five new compounds f1-f5 were prepared by conjugation of the 9a-(γ-aminopropil) azithromycin derivative and the newly synthesized thiosemicarbazides e1-e5. The synthesized compounds were purified by column chromatography. The structures of novel macrozones were proposed on the basis of recorded one- and two-dimensional NMR spectra and the MS spectra, respectively.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:240827
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2021-02-13
Terms of useLicence In copyright icon
Created on2020-03-05 15:13:24